Drug interactions
Dopamine + Selegiline transdermal
Severity: Contraindicated
Dopamine and Selegiline transdermal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is a monoamine oxidase inhibitor, and inhibited MAO greatly potentiates the pressor effect of dopamine. This may cause severe hypertensive crisis.
What this interaction means in plain words
Dopamine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition reduces dopamine breakdown and increases norepinephrine stores, amplifying sympathomimetic effects.
What to do
Avoid; if dopamine is essential, stop selegiline and use a markedly reduced starting dose with close blood pressure monitoring only in an emergency.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
- Desipramine + Dopamine Major
- Dextroamphetamine + Dopamine Major
Frequently asked questions
Can I take Dopamine with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Dopamine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline is a monoamine oxidase inhibitor, and inhibited MAO greatly potentiates the pressor effect of dopamine. This may cause severe hypertensive crisis.
How serious is the interaction between Dopamine and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; if dopamine is essential, stop selegiline and use a markedly reduced starting dose with close blood pressure monitoring only in an emergency.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Amitriptyline. The full list is on the Dopamine page.
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