Interazioni tra farmaci
Doravirine + Phenytoin
Gravità: Controindicata
Doravirine and Phenytoin: contraindicated interaction.
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Sintesi
Phenytoin markedly lowers doravirine concentrations, which may result in loss of virologic response and NNRTI resistance.
Cosa significa questa interazione in parole semplici
Doravirine and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Doravirine belongs to Anti Virals; Phenytoin belongs to Central Nervous System.
Perché avviene
Phenytoin induces CYP3A4, which is the main metabolic pathway of doravirine.
Cosa fare
Do not co-administer; use a non-inducing anticonvulsant. Doravirine labeling also advises against starting it soon after inducer discontinuation until induction wanes.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Phenytoin
- Artemether / lumefantrine + Phenytoin Controindicata
- Bictegravir + Phenytoin Controindicata
- Cabotegravir + Phenytoin Controindicata
- Elbasvir / grazoprevir + Phenytoin Controindicata
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Controindicata
- Ensitrelvir + Phenytoin Controindicata
Altre interazioni di Doravirine
- Amobarbital + Doravirine Controindicata
- Apalutamide + Doravirine Controindicata
- Carbamazepine + Doravirine Controindicata
- Doravirine + Efavirenz Controindicata
- Doravirine + Enzalutamide Controindicata
- Doravirine + Mitotane Controindicata
Domande frequenti
Can I take Doravirine with Phenytoin?
MediHelp rates the interaction as contraindicated. Doravirine and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin markedly lowers doravirine concentrations, which may result in loss of virologic response and NNRTI resistance.
How serious is the interaction between Doravirine and Phenytoin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-inducing anticonvulsant. Doravirine labeling also advises against starting it soon after inducer discontinuation until induction wanes.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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