Interazioni tra farmaci
Ensitrelvir + Phenytoin
Gravità: Controindicata
Ensitrelvir and Phenytoin: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Phenytoin is expected to lower ensitrelvir exposure significantly, risking inadequate antiviral effect. Labeling contraindicates strong CYP3A inducers with ensitrelvir.
Cosa significa questa interazione in parole semplici
Ensitrelvir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ensitrelvir belongs to Anti Virals; Phenytoin belongs to Central Nervous System.
Perché avviene
Phenytoin induces CYP3A4, increasing ensitrelvir clearance.
Cosa fare
Avoid coadministration and use an alternative COVID-19 antiviral not affected by induction. Use a non-inducing anticonvulsant if the patient's seizure management allows.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Ensitrelvir
- Apalutamide + Ensitrelvir Controindicata
- Carbamazepine + Ensitrelvir Controindicata
- Colchicine + Ensitrelvir Controindicata
- Ensitrelvir + Enzalutamide Controindicata
- Ensitrelvir + Eplerenone Controindicata
- Ensitrelvir + Finerenone Controindicata
Altre interazioni di Phenytoin
- Artemether / lumefantrine + Phenytoin Controindicata
- Bictegravir + Phenytoin Controindicata
- Cabotegravir + Phenytoin Controindicata
- Doravirine + Phenytoin Controindicata
- Elbasvir / grazoprevir + Phenytoin Controindicata
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Controindicata
Domande frequenti
Can I take Ensitrelvir with Phenytoin?
MediHelp rates the interaction as contraindicated. Ensitrelvir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin is expected to lower ensitrelvir exposure significantly, risking inadequate antiviral effect. Labeling contraindicates strong CYP3A inducers with ensitrelvir.
How serious is the interaction between Ensitrelvir and Phenytoin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and use an alternative COVID-19 antiviral not affected by induction. Use a non-inducing anticonvulsant if the patient's seizure management allows.
What other medicines interact with Ensitrelvir?
MediHelp also lists interactions of Ensitrelvir with, for example, Apalutamide, Carbamazepine, Colchicine. The full list is on the Ensitrelvir page.
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