Interazioni tra farmaci
Enalapril-hydrochlorothiazide + Protein a column
Gravità: Controindicata
Enalapril-hydrochlorothiazide and Protein a column: contraindicated interaction.
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Sintesi
Patients on ACE inhibitors undergoing apheresis with a protein A immunoadsorption column have developed anaphylactoid reactions. Bradykinin accumulates because ACE inhibition blocks its breakdown, and column treatment can further activate bradykinin-related pathways.
Cosa significa questa interazione in parole semplici
Enalapril-hydrochlorothiazide and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
ACE inhibitors block kininase II degradation of bradykinin, which accumulates during immunoadsorption and triggers anaphylactoid reactions.
Cosa fare
Stop the ACE inhibitor well before the procedure (labeling advises about 72 hours) and use a non-ACE-inhibitor antihypertensive meanwhile.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Controindicata
- Dofetilide + Enalapril-hydrochlorothiazide Controindicata
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Controindicata
- Amifostine + Enalapril-hydrochlorothiazide Maggiore
- Amiloride + Enalapril-hydrochlorothiazide Maggiore
- Azathioprine + Enalapril-hydrochlorothiazide Maggiore
Domande frequenti
Can I take Enalapril-hydrochlorothiazide with Protein a column?
MediHelp rates the interaction as contraindicated. Enalapril-hydrochlorothiazide and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Patients on ACE inhibitors undergoing apheresis with a protein A immunoadsorption column have developed anaphylactoid reactions. Bradykinin accumulates because ACE inhibition blocks its breakdown, and column treatment can further activate bradykinin-related pathways.
How serious is the interaction between Enalapril-hydrochlorothiazide and Protein a column?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop the ACE inhibitor well before the procedure (labeling advises about 72 hours) and use a non-ACE-inhibitor antihypertensive meanwhile.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Enalapril-hydrochlorothiazide page.
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