Interazioni tra farmaci
Azathioprine + Enalapril-hydrochlorothiazide
Gravità: Maggiore
Azathioprine and Enalapril-hydrochlorothiazide: major interaction.
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Sintesi
ACE inhibitors given with azathioprine have been associated with anemia and leukopenia, particularly in renal impairment or transplant recipients. The effect can be significant and may require dose reduction or discontinuation of one drug.
Cosa significa questa interazione in parole semplici
Azathioprine and Enalapril-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Perché avviene
ACE inhibitors may reduce erythropoietin and bone marrow response, adding to azathioprine myelosuppression; mechanism not fully established.
Cosa fare
Monitor complete blood counts regularly, especially during initiation. Reduce or stop azathioprine if cytopenias develop.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Controindicata
- Dofetilide + Enalapril-hydrochlorothiazide Controindicata
- Enalapril-hydrochlorothiazide + Protein a column Controindicata
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Controindicata
- Amifostine + Enalapril-hydrochlorothiazide Maggiore
- Amiloride + Enalapril-hydrochlorothiazide Maggiore
Altre interazioni di Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Controindicata
- Azathioprine + Bcg vaccine live Controindicata
- Azathioprine + Febuxostat Controindicata
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Controindicata
- Azathioprine + Measles mumps and rubella vaccine Controindicata
- Azathioprine + Measles mumps and rubella vaccine live Controindicata
Domande frequenti
Can I take Azathioprine with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as major. Azathioprine and Enalapril-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. ACE inhibitors given with azathioprine have been associated with anemia and leukopenia, particularly in renal impairment or transplant recipients. The effect can be significant and may require dose reduction or discontinuation of one drug.
How serious is the interaction between Azathioprine and Enalapril-hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly, especially during initiation. Reduce or stop azathioprine if cytopenias develop.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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