Interazioni tra farmaci
Ethinyl estradiol-drospirenone + Fezolinetant
Gravità: Controindicata
Ethinyl estradiol-drospirenone and Fezolinetant: contraindicated interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Fezolinetant is metabolized mainly by CYP1A2, and ethinyl estradiol is a weak CYP1A2 inhibitor that can raise fezolinetant exposure. Fezolinetant labeling contraindicates use with CYP1A2 inhibitors, and its indication for menopausal vasomotor symptoms means combined contraceptive use is rarely appropriate anyway. Increased exposure raises the risk of hepatotoxicity.
Cosa significa questa interazione in parole semplici
Ethinyl estradiol-drospirenone and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ethinyl estradiol-drospirenone belongs to Endocrine; Fezolinetant belongs to Endocrine.
Perché avviene
Ethinyl estradiol inhibits CYP1A2, reducing fezolinetant metabolism and increasing its plasma concentration.
Cosa fare
Avoid coadministration. Use an alternative approach for vasomotor symptoms or contraception, and monitor liver tests if fezolinetant is used.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Ethinyl estradiol-drospirenone e Fezolinetant, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Controindicata
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Controindicata
- Ethinyl estradiol-drospirenone + Tranexamic acid Controindicata
- Aminocaproic acid + Ethinyl estradiol-drospirenone Maggiore
- Amobarbital + Ethinyl estradiol-drospirenone Maggiore
- Anastrozole + Ethinyl estradiol-drospirenone Maggiore
Altre interazioni di Fezolinetant
- Cimetidine + Fezolinetant Controindicata
- Ciprofloxacin + Fezolinetant Controindicata
- Desogestrel-ethinyl estradiol + Fezolinetant Controindicata
- Estradiol + Fezolinetant Controindicata
- Ethinyl estradiol-levonorgestrel + Fezolinetant Controindicata
- Ethinyl estradiol-norgestimate + Fezolinetant Controindicata
Domande frequenti
Can I take Ethinyl estradiol-drospirenone with Fezolinetant?
MediHelp rates the interaction as contraindicated. Ethinyl estradiol-drospirenone and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fezolinetant is metabolized mainly by CYP1A2, and ethinyl estradiol is a weak CYP1A2 inhibitor that can raise fezolinetant exposure. Fezolinetant labeling contraindicates use with CYP1A2 inhibitors, and its indication for menopausal vasomotor symptoms means combined contraceptive use is rarely appropriate anyway. Increased exposure raises the risk of hepatotoxicity.
How serious is the interaction between Ethinyl estradiol-drospirenone and Fezolinetant?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. Use an alternative approach for vasomotor symptoms or contraception, and monitor liver tests if fezolinetant is used.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-drospirenone page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
