Interazioni tra farmaci
Desogestrel-ethinyl estradiol + Fezolinetant
Gravità: Controindicata
Desogestrel-ethinyl estradiol and Fezolinetant: contraindicated interaction.
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Sintesi
Fezolinetant is metabolized mainly by CYP1A2, and ethinyl estradiol is a weak CYP1A2 inhibitor that can raise fezolinetant exposure. Fezolinetant labeling contraindicates use with CYP1A2 inhibitors, and its indication for menopausal vasomotor symptoms means combined contraceptive use is rarely appropriate anyway. Increased exposure raises the risk of hepatotoxicity.
Cosa significa questa interazione in parole semplici
Desogestrel-ethinyl estradiol and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Desogestrel-ethinyl estradiol belongs to Endocrine; Fezolinetant belongs to Endocrine.
Perché avviene
Ethinyl estradiol inhibits CYP1A2, reducing fezolinetant metabolism and increasing its plasma concentration.
Cosa fare
Avoid coadministration. Use an alternative approach for vasomotor symptoms or contraception, and monitor liver tests if fezolinetant is used.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Desogestrel-ethinyl estradiol
- Aminocaproic acid + Desogestrel-ethinyl estradiol Maggiore
- Amobarbital + Desogestrel-ethinyl estradiol Maggiore
- Anastrozole + Desogestrel-ethinyl estradiol Maggiore
- Apalutamide + Desogestrel-ethinyl estradiol Maggiore
- Atazanavir + Desogestrel-ethinyl estradiol Maggiore
- Belzutifan + Desogestrel-ethinyl estradiol Maggiore
Altre interazioni di Fezolinetant
- Cimetidine + Fezolinetant Controindicata
- Ciprofloxacin + Fezolinetant Controindicata
- Estradiol + Fezolinetant Controindicata
- Ethinyl estradiol-drospirenone + Fezolinetant Controindicata
- Ethinyl estradiol-levonorgestrel + Fezolinetant Controindicata
- Ethinyl estradiol-norgestimate + Fezolinetant Controindicata
Domande frequenti
Can I take Desogestrel-ethinyl estradiol with Fezolinetant?
MediHelp rates the interaction as contraindicated. Desogestrel-ethinyl estradiol and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fezolinetant is metabolized mainly by CYP1A2, and ethinyl estradiol is a weak CYP1A2 inhibitor that can raise fezolinetant exposure. Fezolinetant labeling contraindicates use with CYP1A2 inhibitors, and its indication for menopausal vasomotor symptoms means combined contraceptive use is rarely appropriate anyway. Increased exposure raises the risk of hepatotoxicity.
How serious is the interaction between Desogestrel-ethinyl estradiol and Fezolinetant?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. Use an alternative approach for vasomotor symptoms or contraception, and monitor liver tests if fezolinetant is used.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Aminocaproic acid, Amobarbital, Anastrozole. The full list is on the Desogestrel-ethinyl estradiol page.
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