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Interazioni tra farmaci

Fludrocortisone + Mifepristone

Gravità: Controindicata

Fludrocortisone and Mifepristone: contraindicated interaction.

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Sintesi

Mifepristone is an antiglucocorticoid, and its labelling for abortion contraindicates long-term corticosteroid therapy because glucocorticoid replacement may be rendered ineffective. Adrenal crisis is a concern in patients taking fludrocortisone with glucocorticoid replacement.

Cosa significa questa interazione in parole semplici

Fludrocortisone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Fludrocortisone belongs to Endocrine; Mifepristone belongs to Endocrine.

Livello di evidenza: Moderate

Perché avviene

Glucocorticoid receptor blockade reducing replacement efficacy

Cosa fare

Avoid; if mifepristone is essential, coordinate with an endocrinologist and increase glucocorticoid cover as needed.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Fludrocortisone with Mifepristone?

MediHelp rates the interaction as contraindicated. Fludrocortisone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone is an antiglucocorticoid, and its labelling for abortion contraindicates long-term corticosteroid therapy because glucocorticoid replacement may be rendered ineffective. Adrenal crisis is a concern in patients taking fludrocortisone with glucocorticoid replacement.

How serious is the interaction between Fludrocortisone and Mifepristone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; if mifepristone is essential, coordinate with an endocrinologist and increase glucocorticoid cover as needed.

What other medicines interact with Fludrocortisone?

MediHelp also lists interactions of Fludrocortisone with, for example, Aldesleukin, Amphotericin b, Bcg vaccine live. The full list is on the Fludrocortisone page.

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