Interazioni tra farmaci
Gentamicin + Zoledronic acid
Gravità: Moderata
Gentamicin and Zoledronic acid: moderate interaction.
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Sintesi
Aminoglycosides can cause renal magnesium and calcium wasting and are nephrotoxic. Combined with zoledronic acid, this may increase the risk of hypocalcemia and renal injury. Zoledronic acid labeling advises caution with nephrotoxic drugs.
Cosa significa questa interazione in parole semplici
Gentamicin and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Zoledronic acid belongs to Musculoskeletal.
Perché avviene
Additive calcium lowering and potential additive nephrotoxicity through aminoglycoside-induced renal electrolyte wasting.
Cosa fare
Monitor serum calcium, magnesium and creatinine regularly. Replace electrolytes as needed and limit aminoglycoside duration.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Zoledronic acid
- Amikacin + Zoledronic acid Moderata
- Bumetanide + Zoledronic acid Moderata
- Dichlorphenamide + Zoledronic acid Moderata
- Ethacrynic acid + Zoledronic acid Moderata
- Foscarnet + Zoledronic acid Moderata
- Human parathyroid hormone recombinant + Zoledronic acid Moderata
Altre interazioni di Gentamicin
- Cidofovir + Gentamicin Controindicata
- Adefovir + Gentamicin Maggiore
- Amikacin + Gentamicin Maggiore
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Maggiore
- Amphotericin b deoxycholate + Gentamicin Maggiore
- Amphotericin b + Gentamicin Maggiore
Domande frequenti
Can I take Gentamicin with Zoledronic acid?
MediHelp rates the interaction as moderate. Gentamicin and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides can cause renal magnesium and calcium wasting and are nephrotoxic. Combined with zoledronic acid, this may increase the risk of hypocalcemia and renal injury. Zoledronic acid labeling advises caution with nephrotoxic drugs.
How serious is the interaction between Gentamicin and Zoledronic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, magnesium and creatinine regularly. Replace electrolytes as needed and limit aminoglycoside duration.
What other medicines interact with Zoledronic acid?
MediHelp also lists interactions of Zoledronic acid with, for example, Amikacin, Bumetanide, Dichlorphenamide. The full list is on the Zoledronic acid page.
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