Drug interactions
Gentamicin + Zoledronic acid
Severity: Moderate
Gentamicin and Zoledronic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides can cause renal magnesium and calcium wasting and are nephrotoxic. Combined with zoledronic acid, this may increase the risk of hypocalcemia and renal injury. Zoledronic acid labeling advises caution with nephrotoxic drugs.
What this interaction means in plain words
Gentamicin and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Zoledronic acid belongs to Musculoskeletal.
Why it happens
Additive calcium lowering and potential additive nephrotoxicity through aminoglycoside-induced renal electrolyte wasting.
What to do
Monitor serum calcium, magnesium and creatinine regularly. Replace electrolytes as needed and limit aminoglycoside duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zoledronic acid
- Amikacin + Zoledronic acid Moderate
- Bumetanide + Zoledronic acid Moderate
- Dichlorphenamide + Zoledronic acid Moderate
- Ethacrynic acid + Zoledronic acid Moderate
- Foscarnet + Zoledronic acid Moderate
- Human parathyroid hormone recombinant + Zoledronic acid Moderate
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Zoledronic acid?
MediHelp rates the interaction as moderate. Gentamicin and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides can cause renal magnesium and calcium wasting and are nephrotoxic. Combined with zoledronic acid, this may increase the risk of hypocalcemia and renal injury. Zoledronic acid labeling advises caution with nephrotoxic drugs.
How serious is the interaction between Gentamicin and Zoledronic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, magnesium and creatinine regularly. Replace electrolytes as needed and limit aminoglycoside duration.
What other medicines interact with Zoledronic acid?
MediHelp also lists interactions of Zoledronic acid with, for example, Amikacin, Bumetanide, Dichlorphenamide. The full list is on the Zoledronic acid page.
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