Interazioni tra farmaci
Imipenem / cilastatin + Valproic acid
Gravità: Controindicata
Imipenem / cilastatin and Valproic acid: contraindicated interaction.
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Sintesi
Carbapenems rapidly and substantially lower serum valproate concentrations, often within a day, and can precipitate breakthrough seizures. The effect may persist for days after the carbapenem is stopped and is not reliably overcome by raising the valproate dose.
Cosa significa questa interazione in parole semplici
Imipenem / cilastatin and Valproic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Carbapenems inhibit acylpeptide hydrolase, blocking hydrolysis of valproate glucuronide back to valproate, and may also reduce its absorption or increase its distribution into red cells.
Cosa fare
Avoid the combination and use a non-carbapenem antibiotic. If a carbapenem is essential, add alternative anticonvulsant cover and monitor valproate levels and seizure activity.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Valproic acid
- Ertapenem + Valproic acid Controindicata
- Imipenem / cilastatin / relebactam + Valproic acid Controindicata
- Meropenem / vaborbactam + Valproic acid Controindicata
- Meropenem + Valproic acid Controindicata
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Maggiore
- Cilastatin-imipenem + Valproic acid Maggiore
Domande frequenti
Can I take Imipenem / cilastatin with Valproic acid?
MediHelp rates the interaction as contraindicated. Imipenem / cilastatin and Valproic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbapenems rapidly and substantially lower serum valproate concentrations, often within a day, and can precipitate breakthrough seizures. The effect may persist for days after the carbapenem is stopped and is not reliably overcome by raising the valproate dose.
How serious is the interaction between Imipenem / cilastatin and Valproic acid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-carbapenem antibiotic. If a carbapenem is essential, add alternative anticonvulsant cover and monitor valproate levels and seizure activity.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Meropenem / vaborbactam. The full list is on the Valproic acid page.
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