Vai al contenuto
MediHelp
MediHelp Riferimento sui farmaci

Interazioni tra farmaci

Meropenem + Valproic acid

Gravità: Controindicata

Meropenem and Valproic acid: contraindicated interaction.

Ultimo aggiornamento

Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.

Il contenuto clinico di questa pagina è disponibile solo in inglese.

Sintesi

Meropenem causes a rapid and marked fall in serum valproic acid concentrations, often within a day or two of starting. Levels can drop below the therapeutic range, resulting in breakthrough seizures, and the effect may persist for days to weeks after the carbapenem is stopped.

Cosa significa questa interazione in parole semplici

Meropenem and Valproic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Meropenem belongs to Anti Bacterial; Valproic acid belongs to Central Nervous System.

Livello di evidenza: High

Perché avviene

Carbapenems are thought to inhibit hydrolysis of valproate glucuronide back to valproate and may reduce its absorption and red cell uptake, lowering valproate concentrations.

Cosa fare

Avoid the combination and use a non-carbapenem antibiotic. If a carbapenem is unavoidable, add an alternative anticonvulsant, since increasing the valproate dose does not reliably overcome the effect.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Per gli utenti Pro+

Sblocca la pagina completa

Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Meropenem e Valproic acid, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Crea un account gratuito Accedi

Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.

Domande frequenti

Can I take Meropenem with Valproic acid?

MediHelp rates the interaction as contraindicated. Meropenem and Valproic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Meropenem causes a rapid and marked fall in serum valproic acid concentrations, often within a day or two of starting. Levels can drop below the therapeutic range, resulting in breakthrough seizures, and the effect may persist for days to weeks after the carbapenem is stopped.

How serious is the interaction between Meropenem and Valproic acid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-carbapenem antibiotic. If a carbapenem is unavoidable, add an alternative anticonvulsant, since increasing the valproate dose does not reliably overcome the effect.

What other medicines interact with Meropenem?

MediHelp also lists interactions of Meropenem with, for example, Typhoid vaccine live, Amifampridine, Cholera vaccine. The full list is on the Meropenem page.

Monografie complete, posologie e verifica delle interazioni nell'app MediHelp

Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.

Scarica suApp Store Disponibile suGoogle Play

Sfoglia dalla A alla Z · Interazioni tra farmaci

Scarica l'app Accedi