Interazioni tra farmaci
Isavuconazole + Ritonavir
Gravità: Controindicata
Isavuconazole and Ritonavir: contraindicated interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
High-dose ritonavir can induce metabolism of isavuconazole and lower its exposure, whereas lower doses act as a CYP3A4 inhibitor and may raise it. The net effect depends on dose and can compromise efficacy or increase toxicity.
Cosa significa questa interazione in parole semplici
Isavuconazole and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isavuconazole belongs to Anti Fungals; Ritonavir belongs to Anti Virals.
Perché avviene
Dose-dependent mixed CYP3A4 effects of ritonavir; high doses induce isavuconazole clearance.
Cosa fare
Avoid high-dose ritonavir with isavuconazole. With low-dose boosting, monitor isavuconazole levels, response and adverse effects.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Isavuconazole e Ritonavir, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Isavuconazole
- Carbamazepine + Isavuconazole Controindicata
- Efavirenz + Isavuconazole Controindicata
- Etravirine + Isavuconazole Controindicata
- Isavuconazole + Ketoconazole Controindicata
- Isavuconazole + Phenobarbitone Controindicata
- Isavuconazole + Phenytoin Controindicata
Altre interazioni di Ritonavir
- Alfuzosin + Ritonavir Controindicata
- Amiodarone + Ritonavir Controindicata
- Avanafil + Ritonavir Controindicata
- Colchicine + Ritonavir Controindicata
- Dronedarone + Ritonavir Controindicata
- Eletriptan + Ritonavir Controindicata
Domande frequenti
Can I take Isavuconazole with Ritonavir?
MediHelp rates the interaction as contraindicated. Isavuconazole and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. High-dose ritonavir can induce metabolism of isavuconazole and lower its exposure, whereas lower doses act as a CYP3A4 inhibitor and may raise it. The net effect depends on dose and can compromise efficacy or increase toxicity.
How serious is the interaction between Isavuconazole and Ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid high-dose ritonavir with isavuconazole. With low-dose boosting, monitor isavuconazole levels, response and adverse effects.
What other medicines interact with Isavuconazole?
MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Efavirenz, Etravirine. The full list is on the Isavuconazole page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
