Interazioni tra farmaci
Ketoconazole + Tolvaptan
Gravità: Controindicata
Ketoconazole and Tolvaptan: contraindicated interaction.
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Sintesi
Ketoconazole greatly increases tolvaptan exposure. This can cause excessively rapid aquaresis, dehydration, hypernatremia and osmotic demyelination risk from overly fast sodium correction.
Cosa significa questa interazione in parole semplici
Ketoconazole and Tolvaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ketoconazole belongs to Anti Fungals; Tolvaptan belongs to Endocrine.
Perché avviene
Strong CYP3A4 inhibition markedly decreases tolvaptan metabolism.
Cosa fare
Avoid the combination; strong CYP3A4 inhibitors are contraindicated with tolvaptan. Use an alternative antifungal, or hold tolvaptan during treatment.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Ketoconazole
- Alfuzosin + Ketoconazole Controindicata
- Alprazolam + Ketoconazole Controindicata
- Avanafil + Ketoconazole Controindicata
- Conivaptan + Ketoconazole Controindicata
- Dihydroergotamine intranasal + Ketoconazole Controindicata
- Dihydroergotamine + Ketoconazole Controindicata
Altre interazioni di Tolvaptan
- Atazanavir + Tolvaptan Controindicata
- Ceritinib + Tolvaptan Controindicata
- Cobicistat + Tolvaptan Controindicata
- Conivaptan + Tolvaptan Controindicata
- Darunavir + Tolvaptan Controindicata
- Idelalisib + Tolvaptan Controindicata
Domande frequenti
Can I take Ketoconazole with Tolvaptan?
MediHelp rates the interaction as contraindicated. Ketoconazole and Tolvaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole greatly increases tolvaptan exposure. This can cause excessively rapid aquaresis, dehydration, hypernatremia and osmotic demyelination risk from overly fast sodium correction.
How serious is the interaction between Ketoconazole and Tolvaptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; strong CYP3A4 inhibitors are contraindicated with tolvaptan. Use an alternative antifungal, or hold tolvaptan during treatment.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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