Interazioni tra farmaci
Levoketoconazole + Sirolimus
Gravità: Controindicata
Levoketoconazole and Sirolimus: contraindicated interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Levoketoconazole is a strong CYP3A4 and P-gp inhibitor and can markedly raise sirolimus exposure. This may cause serious toxicity, including myelosuppression, hyperlipidemia, infection and impaired wound healing.
Cosa significa questa interazione in parole semplici
Levoketoconazole and Sirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levoketoconazole belongs to Endocrine; Sirolimus belongs to Miscellaneous.
Perché avviene
Strong inhibition of CYP3A4 and P-glycoprotein reduces sirolimus metabolism and efflux.
Cosa fare
Avoid the combination and use an alternative treatment. If the interaction cannot be avoided, specialist guidance and very close sirolimus level monitoring are needed.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Levoketoconazole e Sirolimus, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Controindicata
- Bcg vaccine live + Sirolimus Controindicata
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Controindicata
- Ketoconazole + Sirolimus Controindicata
- Measles mumps and rubella vaccine live + Sirolimus Controindicata
- Measles mumps and rubella vaccine + Sirolimus Controindicata
Altre interazioni di Levoketoconazole
- Alfuzosin + Levoketoconazole Controindicata
- Alprazolam + Levoketoconazole Controindicata
- Amiodarone + Levoketoconazole Controindicata
- Avanafil + Levoketoconazole Controindicata
- Cisapride + Levoketoconazole Controindicata
- Clarithromycin + Levoketoconazole Controindicata
Domande frequenti
Can I take Levoketoconazole with Sirolimus?
MediHelp rates the interaction as contraindicated. Levoketoconazole and Sirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A4 and P-gp inhibitor and can markedly raise sirolimus exposure. This may cause serious toxicity, including myelosuppression, hyperlipidemia, infection and impaired wound healing.
How serious is the interaction between Levoketoconazole and Sirolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative treatment. If the interaction cannot be avoided, specialist guidance and very close sirolimus level monitoring are needed.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
