Interazioni tra farmaci
Clarithromycin + Levoketoconazole
Gravità: Controindicata
Clarithromycin and Levoketoconazole: contraindicated interaction.
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Sintesi
Levoketoconazole is a strong CYP3A4 inhibitor that can raise clarithromycin levels, and both drugs prolong the QT interval. Levoketoconazole is contraindicated with other QT-prolonging CYP3A4 substrates, so the combination carries a serious arrhythmia risk.
Cosa significa questa interazione in parole semplici
Clarithromycin and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Levoketoconazole belongs to Endocrine.
Perché avviene
CYP3A4 inhibition increases clarithromycin exposure, with additive QT prolongation.
Cosa fare
Do not co-administer; use a non-QT-prolonging antibiotic that is not a CYP3A4 substrate or inhibitor.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Clarithromycin
- Astemizole + Clarithromycin Controindicata
- Avanafil + Clarithromycin Controindicata
- Cisapride + Clarithromycin Controindicata
- Clarithromycin + Colchicine Controindicata
- Clarithromycin + Conivaptan Controindicata
- Clarithromycin + Dihydroergotamine Controindicata
Altre interazioni di Levoketoconazole
- Alfuzosin + Levoketoconazole Controindicata
- Alprazolam + Levoketoconazole Controindicata
- Amiodarone + Levoketoconazole Controindicata
- Avanafil + Levoketoconazole Controindicata
- Cisapride + Levoketoconazole Controindicata
- Colchicine + Levoketoconazole Controindicata
Domande frequenti
Can I take Clarithromycin with Levoketoconazole?
MediHelp rates the interaction as contraindicated. Clarithromycin and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A4 inhibitor that can raise clarithromycin levels, and both drugs prolong the QT interval. Levoketoconazole is contraindicated with other QT-prolonging CYP3A4 substrates, so the combination carries a serious arrhythmia risk.
How serious is the interaction between Clarithromycin and Levoketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-QT-prolonging antibiotic that is not a CYP3A4 substrate or inhibitor.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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