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Interazioni tra farmaci

Magnesium + Sodium polystyrene sulfonate

Gravità: Moderata

Magnesium and Sodium polystyrene sulfonate: moderate interaction.

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Sintesi

Sodium polystyrene sulfonate binds magnesium in the gut, so it may lower magnesium and cause hypomagnesemia with prolonged use. The legacy concern of raised magnesium levels is not well supported, and the mechanism is poorly characterized.

Cosa significa questa interazione in parole semplici

Magnesium and Sodium polystyrene sulfonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Magnesium belongs to Gastrointestinal Tract; Sodium polystyrene sulfonate belongs to Miscellaneous.

Livello di evidenza: Moderate

Perché avviene

The resin exchanges sodium for cations including magnesium in the intestinal lumen, increasing fecal magnesium loss and also binding oral magnesium.

Cosa fare

Monitor serum magnesium, potassium and calcium during repeated resin use. Separate oral magnesium from the resin by at least 3 hours and replace magnesium if low.

Cosa chiedere al farmacista

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Magnesium with Sodium polystyrene sulfonate?

MediHelp rates the interaction as moderate. Magnesium and Sodium polystyrene sulfonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium polystyrene sulfonate binds magnesium in the gut, so it may lower magnesium and cause hypomagnesemia with prolonged use. The legacy concern of raised magnesium levels is not well supported, and the mechanism is poorly characterized.

How serious is the interaction between Magnesium and Sodium polystyrene sulfonate?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium, potassium and calcium during repeated resin use. Separate oral magnesium from the resin by at least 3 hours and replace magnesium if low.

What other medicines interact with Magnesium?

MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Pancuronium, Rocuronium. The full list is on the Magnesium page.

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