Interazioni tra farmaci
Calcium carbonate + Sodium polystyrene sulfonate
Gravità: Moderata
Calcium carbonate and Sodium polystyrene sulfonate: moderate interaction.
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Sintesi
Sodium polystyrene sulfonate can bind calcium in the gut, and the antacid effect of calcium carbonate may be offset by cation exchange. Reduced binding of bicarbonate-producing cations has been associated with metabolic alkalosis, especially in renal impairment. Clinical impact is usually modest but can matter in dialysis patients.
Cosa significa questa interazione in parole semplici
Calcium carbonate and Sodium polystyrene sulfonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Sodium polystyrene sulfonate belongs to Miscellaneous.
Perché avviene
Non-absorbed cation-exchange resin binds calcium and other cations in the gut, and combined with non-absorbable antacid it can leave bicarbonate unneutralized and cause systemic alkalosis.
Cosa fare
Separate administration by at least 3 hours (6 hours in gastroparesis) and monitor serum calcium, potassium and acid-base status in renal impairment.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Calcium carbonate
Altre interazioni di Sodium polystyrene sulfonate
- Meloxicam + Sodium polystyrene sulfonate Maggiore
- Sodium polystyrene sulfonate + Sorbitol Maggiore
- Deflazacort + Sodium polystyrene sulfonate Moderata
- Levothyroxine + Sodium polystyrene sulfonate Moderata
- Lithium + Sodium polystyrene sulfonate Moderata
- Magnesium citrate + Sodium polystyrene sulfonate Moderata
Domande frequenti
Can I take Calcium carbonate with Sodium polystyrene sulfonate?
MediHelp rates the interaction as moderate. Calcium carbonate and Sodium polystyrene sulfonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium polystyrene sulfonate can bind calcium in the gut, and the antacid effect of calcium carbonate may be offset by cation exchange. Reduced binding of bicarbonate-producing cations has been associated with metabolic alkalosis, especially in renal impairment. Clinical impact is usually modest but can matter in dialysis patients.
How serious is the interaction between Calcium carbonate and Sodium polystyrene sulfonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration by at least 3 hours (6 hours in gastroparesis) and monitor serum calcium, potassium and acid-base status in renal impairment.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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