Interazioni tra farmaci
Measles mumps and rubella vaccine live + Tacrolimus
Gravità: Controindicata
Measles mumps and rubella vaccine live and Tacrolimus: contraindicated interaction.
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Sintesi
The MMR vaccine contains live attenuated viruses. In tacrolimus-treated patients these viruses may replicate unchecked and cause vaccine-strain disease, and the immune response is likely to be poor.
Cosa significa questa interazione in parole semplici
Measles mumps and rubella vaccine live and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Calcineurin inhibition suppresses cellular immunity, permitting replication of live attenuated vaccine viruses.
Cosa fare
Do not give MMR vaccine to patients on tacrolimus. Vaccinate before transplant or immunosuppression where possible, and check immunity by serology.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Controindicata
- Bcg vaccine live + Tacrolimus Controindicata
- Cidofovir + Tacrolimus Controindicata
- Cyclosporin + Tacrolimus Controindicata
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Controindicata
- Measles mumps and rubella vaccine + Tacrolimus Controindicata
Domande frequenti
Can I take Measles mumps and rubella vaccine live with Tacrolimus?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine live and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The MMR vaccine contains live attenuated viruses. In tacrolimus-treated patients these viruses may replicate unchecked and cause vaccine-strain disease, and the immune response is likely to be poor.
How serious is the interaction between Measles mumps and rubella vaccine live and Tacrolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give MMR vaccine to patients on tacrolimus. Vaccinate before transplant or immunosuppression where possible, and check immunity by serology.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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