Interazioni tra farmaci
Mefloquine + Pimozide
Gravità: Controindicata
Mefloquine and Pimozide: contraindicated interaction.
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Sintesi
Pimozide is a potent QT-prolonging antipsychotic, and mefloquine further lengthens the QT interval. The combination carries a high risk of torsades de pointes and sudden cardiac death.
Cosa significa questa interazione in parole semplici
Mefloquine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mefloquine belongs to Anti Parasitic; Pimozide belongs to Central Nervous System.
Perché avviene
Additive QT prolongation through cardiac potassium channel blockade.
Cosa fare
Do not use together; choose an antimalarial without QT effects. If mefloquine has been taken recently, allow for its long half-life before starting pimozide.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Mefloquine
- Arsenic trioxide + Mefloquine Controindicata
- Dronedarone + Mefloquine Controindicata
- Ibutilide + Mefloquine Controindicata
- Levoketoconazole + Mefloquine Controindicata
- Mefloquine + Nilotinib Controindicata
- Mefloquine + Quinidine Controindicata
Altre interazioni di Pimozide
- Adagrasib + Pimozide Controindicata
- Amiodarone + Pimozide Controindicata
- Amisulpride + Pimozide Controindicata
- Amitriptyline + Pimozide Controindicata
- Amoxapine + Pimozide Controindicata
- Anagrelide + Pimozide Controindicata
Domande frequenti
Can I take Mefloquine with Pimozide?
MediHelp rates the interaction as contraindicated. Mefloquine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pimozide is a potent QT-prolonging antipsychotic, and mefloquine further lengthens the QT interval. The combination carries a high risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Mefloquine and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose an antimalarial without QT effects. If mefloquine has been taken recently, allow for its long half-life before starting pimozide.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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