Interazioni tra farmaci
Levoketoconazole + Mefloquine
Gravità: Controindicata
Levoketoconazole and Mefloquine: contraindicated interaction.
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Sintesi
Levoketoconazole is a strong CYP3A4 inhibitor and also prolongs the QT interval. It can raise mefloquine levels while both drugs add to QT prolongation, which increases the risk of torsades de pointes.
Cosa significa questa interazione in parole semplici
Levoketoconazole and Mefloquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levoketoconazole belongs to Endocrine; Mefloquine belongs to Anti Parasitic.
Perché avviene
Strong CYP3A4 inhibition raises mefloquine exposure, combined with additive QT prolongation.
Cosa fare
Do not coadminister; use an alternative antimalarial. Remember mefloquine's long half-life when starting levoketoconazole after recent use.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Mefloquine
- Arsenic trioxide + Mefloquine Controindicata
- Dronedarone + Mefloquine Controindicata
- Ibutilide + Mefloquine Controindicata
- Mefloquine + Nilotinib Controindicata
- Mefloquine + Pimozide Controindicata
- Mefloquine + Quinidine Controindicata
Altre interazioni di Levoketoconazole
- Alfuzosin + Levoketoconazole Controindicata
- Alprazolam + Levoketoconazole Controindicata
- Amiodarone + Levoketoconazole Controindicata
- Avanafil + Levoketoconazole Controindicata
- Cisapride + Levoketoconazole Controindicata
- Clarithromycin + Levoketoconazole Controindicata
Domande frequenti
Can I take Levoketoconazole with Mefloquine?
MediHelp rates the interaction as contraindicated. Levoketoconazole and Mefloquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A4 inhibitor and also prolongs the QT interval. It can raise mefloquine levels while both drugs add to QT prolongation, which increases the risk of torsades de pointes.
How serious is the interaction between Levoketoconazole and Mefloquine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antimalarial. Remember mefloquine's long half-life when starting levoketoconazole after recent use.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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