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Interazioni tra farmaci

Megestrol + Warfarin

Gravità: Moderata

Megestrol and Warfarin: moderate interaction.

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Sintesi

Increases in INR and bleeding have been reported in patients on warfarin who start megestrol. The reports are limited, and the effect varies between patients.

Cosa significa questa interazione in parole semplici

Megestrol and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Megestrol belongs to Oncology; Warfarin belongs to Cardiovascular.

Livello di evidenza: Low

Perché avviene

The mechanism is not established; altered warfarin metabolism or protein binding has been proposed.

Cosa fare

Check INR within a week of starting or stopping megestrol and adjust the warfarin dose accordingly.

Cosa chiedere al farmacista

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Megestrol with Warfarin?

MediHelp rates the interaction as moderate. Megestrol and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Increases in INR and bleeding have been reported in patients on warfarin who start megestrol. The reports are limited, and the effect varies between patients.

How serious is the interaction between Megestrol and Warfarin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR within a week of starting or stopping megestrol and adjust the warfarin dose accordingly.

What other medicines interact with Warfarin?

MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.

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