Interazioni tra farmaci
Meperidine + Rasagiline
Gravità: Controindicata
Meperidine and Rasagiline: contraindicated interaction.
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Sintesi
Rasagiline labeling warns against meperidine because of reports of serious, sometimes fatal serotonin syndrome-like reactions with MAO inhibitors. Symptoms can include agitation, hyperthermia, rigidity and autonomic instability.
Cosa significa questa interazione in parole semplici
Meperidine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Meperidine belongs to Musculoskeletal; Rasagiline belongs to Central Nervous System.
Perché avviene
MAO inhibition combined with meperidine's serotonin reuptake inhibition increases serotonergic activity.
Cosa fare
Avoid the combination and allow an adequate washout interval, generally at least 14 days after rasagiline. Use a different analgesic.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Meperidine
- Alvimopan + Meperidine Controindicata
- Isocarboxazid + Meperidine Controindicata
- Meperidine + Methylene blue Controindicata
- Meperidine + Olanzapine / samidorphan Controindicata
- Meperidine + Phenelzine Controindicata
- Meperidine + Procarbazine Controindicata
Altre interazioni di Rasagiline
- Atomoxetine + Rasagiline Controindicata
- Brimonidine + Rasagiline Controindicata
- Bupropion-naltrexone + Rasagiline Controindicata
- Bupropion + Rasagiline Controindicata
- Clomipramine + Rasagiline Controindicata
- Desvenlafaxine + Rasagiline Controindicata
Domande frequenti
Can I take Meperidine with Rasagiline?
MediHelp rates the interaction as contraindicated. Meperidine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rasagiline labeling warns against meperidine because of reports of serious, sometimes fatal serotonin syndrome-like reactions with MAO inhibitors. Symptoms can include agitation, hyperthermia, rigidity and autonomic instability.
How serious is the interaction between Meperidine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and allow an adequate washout interval, generally at least 14 days after rasagiline. Use a different analgesic.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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