Interazioni tra farmaci
Meperidine + Procarbazine
Gravità: Controindicata
Meperidine and Procarbazine: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Procarbazine has MAO-inhibiting properties, and meperidine with MAO inhibitors can cause severe, sometimes fatal serotonin syndrome or excitatory reactions with hyperthermia. Meperidine is the opioid most associated with this reaction.
Cosa significa questa interazione in parole semplici
Meperidine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Meperidine belongs to Musculoskeletal; Procarbazine belongs to Oncology.
Perché avviene
MAO inhibition combined with meperidine's serotonin reuptake inhibition leading to serotonin excess.
Cosa fare
Do not use together or within 14 days of stopping an MAO inhibitor. Choose a non-serotonergic analgesic such as morphine, with monitoring.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Meperidine
- Alvimopan + Meperidine Controindicata
- Isocarboxazid + Meperidine Controindicata
- Meperidine + Methylene blue Controindicata
- Meperidine + Olanzapine / samidorphan Controindicata
- Meperidine + Phenelzine Controindicata
- Meperidine + Rasagiline Controindicata
Altre interazioni di Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Controindicata
- Amitriptyline + Procarbazine Controindicata
- Amoxapine + Procarbazine Controindicata
- Atomoxetine + Procarbazine Controindicata
- Bcg vaccine live + Procarbazine Controindicata
- Brimonidine + Procarbazine Controindicata
Domande frequenti
Can I take Meperidine with Procarbazine?
MediHelp rates the interaction as contraindicated. Meperidine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has MAO-inhibiting properties, and meperidine with MAO inhibitors can cause severe, sometimes fatal serotonin syndrome or excitatory reactions with hyperthermia. Meperidine is the opioid most associated with this reaction.
How serious is the interaction between Meperidine and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together or within 14 days of stopping an MAO inhibitor. Choose a non-serotonergic analgesic such as morphine, with monitoring.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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