Interazioni tra farmaci
Oxymorphone + Phenelzine
Gravità: Controindicata
Oxymorphone and Phenelzine: contraindicated interaction.
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Sintesi
Opioids given with MAO inhibitors have been associated with serious reactions, including hypotension, CNS depression and in some cases serotonin-like toxicity with hyperthermia. Labeling advises against use during or within 14 days of MAOI therapy.
Cosa significa questa interazione in parole semplici
Oxymorphone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Oxymorphone belongs to Musculoskeletal; Phenelzine belongs to Central Nervous System.
Perché avviene
MAO inhibition potentiates opioid CNS effects and may cause serotonergic or autonomic toxicity; the exact mechanism varies by opioid.
Cosa fare
Do not use oxymorphone during or within 14 days after stopping phenelzine. Choose an alternative analgesic.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Oxymorphone
- Alvimopan + Oxymorphone Controindicata
- Ethanol + Oxymorphone Controindicata
- Isocarboxazid + Oxymorphone Controindicata
- Olanzapine / samidorphan + Oxymorphone Controindicata
- Oxymorphone + Selegiline transdermal Controindicata
- Oxymorphone + Sodium oxybate Controindicata
Altre interazioni di Phenelzine
- 5-HTP + Phenelzine Controindicata
- Amitriptyline + Phenelzine Controindicata
- Amoxapine + Phenelzine Controindicata
- Atomoxetine + Phenelzine Controindicata
- Benzphetamine + Phenelzine Controindicata
- Brimonidine + Phenelzine Controindicata
Domande frequenti
Can I take Oxymorphone with Phenelzine?
MediHelp rates the interaction as contraindicated. Oxymorphone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids given with MAO inhibitors have been associated with serious reactions, including hypotension, CNS depression and in some cases serotonin-like toxicity with hyperthermia. Labeling advises against use during or within 14 days of MAOI therapy.
How serious is the interaction between Oxymorphone and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use oxymorphone during or within 14 days after stopping phenelzine. Choose an alternative analgesic.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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