Interazioni tra farmaci
Pimozide + Quinine
Gravità: Controindicata
Pimozide and Quinine: contraindicated interaction.
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Sintesi
Both drugs prolong the QT interval, and quinine also inhibits CYP2D6, potentially raising pimozide levels. The combination markedly raises the risk of torsades de pointes and sudden cardiac death.
Cosa significa questa interazione in parole semplici
Pimozide and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pimozide belongs to Central Nervous System; Quinine belongs to Anti Parasitic.
Perché avviene
Additive QT prolongation with quinine inhibition of CYP2D6-mediated pimozide metabolism.
Cosa fare
Do not co-administer; use an alternative antimalarial or antipsychotic. If quinine is essential, stop pimozide and monitor the ECG.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Quinine
- Arsenic trioxide + Quinine Controindicata
- Dofetilide + Quinine Controindicata
- Dronedarone + Quinine Controindicata
- Ibutilide + Quinine Controindicata
- Mefloquine + Quinine Controindicata
- Nilotinib + Quinine Controindicata
Altre interazioni di Pimozide
- Adagrasib + Pimozide Controindicata
- Amiodarone + Pimozide Controindicata
- Amisulpride + Pimozide Controindicata
- Amitriptyline + Pimozide Controindicata
- Amoxapine + Pimozide Controindicata
- Anagrelide + Pimozide Controindicata
Domande frequenti
Can I take Pimozide with Quinine?
MediHelp rates the interaction as contraindicated. Pimozide and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and quinine also inhibits CYP2D6, potentially raising pimozide levels. The combination markedly raises the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Pimozide and Quinine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use an alternative antimalarial or antipsychotic. If quinine is essential, stop pimozide and monitor the ECG.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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