Interazioni tra farmaci
Nilotinib + Quinine
Gravità: Controindicata
Nilotinib and Quinine: contraindicated interaction.
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Sintesi
Nilotinib carries a boxed warning for QT prolongation and sudden death, and quinine adds further QT-prolonging effect. Quinine may also raise nilotinib levels through CYP3A4 inhibition, which compounds the risk.
Cosa significa questa interazione in parole semplici
Nilotinib and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Nilotinib belongs to Oncology; Quinine belongs to Anti Parasitic.
Perché avviene
Additive hERG-mediated QT prolongation, with possible CYP3A4 inhibition by quinine increasing nilotinib exposure.
Cosa fare
Do not use together; choose an alternative antimalarial or defer nilotinib if quinine is essential. If unavoidable, use continuous ECG monitoring and electrolyte correction.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Quinine
- Arsenic trioxide + Quinine Controindicata
- Dofetilide + Quinine Controindicata
- Dronedarone + Quinine Controindicata
- Ibutilide + Quinine Controindicata
- Mefloquine + Quinine Controindicata
- Pimozide + Quinine Controindicata
Altre interazioni di Nilotinib
- Amiodarone + Nilotinib Controindicata
- Arsenic trioxide + Nilotinib Controindicata
- Disopyramide + Nilotinib Controindicata
- Dofetilide + Nilotinib Controindicata
- Dronedarone + Nilotinib Controindicata
- Droperidol + Nilotinib Controindicata
Domande frequenti
Can I take Nilotinib with Quinine?
MediHelp rates the interaction as contraindicated. Nilotinib and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nilotinib carries a boxed warning for QT prolongation and sudden death, and quinine adds further QT-prolonging effect. Quinine may also raise nilotinib levels through CYP3A4 inhibition, which compounds the risk.
How serious is the interaction between Nilotinib and Quinine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose an alternative antimalarial or defer nilotinib if quinine is essential. If unavoidable, use continuous ECG monitoring and electrolyte correction.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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