Interazioni tra farmaci
Red yeast rice + Ritonavir
Gravità: Controindicata
Red yeast rice and Ritonavir: contraindicated interaction.
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Sintesi
Red yeast rice contains monacolin K, identical to lovastatin, which is extensively metabolized by CYP3A4. Ritonavir is a potent CYP3A4 inhibitor and can greatly increase statin exposure, leading to myopathy and rhabdomyolysis.
Cosa significa questa interazione in parole semplici
Red yeast rice and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Red yeast rice belongs to Gastrointestinal Tract; Ritonavir belongs to Anti Virals.
Perché avviene
Ritonavir strongly inhibits CYP3A4 and markedly increases monacolin K (lovastatin) exposure.
Cosa fare
Do not combine; stop red yeast rice while on ritonavir. Choose an alternative lipid-lowering agent such as pravastatin or rosuvastatin with dose limits per labeling.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Red yeast rice
- Red yeast rice + Saquinavir Controindicata
- Red yeast rice + Tipranavir Controindicata
- Atazanavir + Red yeast rice Maggiore
- Atorvastatin + Red yeast rice Maggiore
- Conivaptan + Red yeast rice Maggiore
- Cyclosporine + Red yeast rice Maggiore
Altre interazioni di Ritonavir
- Alfuzosin + Ritonavir Controindicata
- Amiodarone + Ritonavir Controindicata
- Avanafil + Ritonavir Controindicata
- Colchicine + Ritonavir Controindicata
- Dronedarone + Ritonavir Controindicata
- Eletriptan + Ritonavir Controindicata
Domande frequenti
Can I take Red yeast rice with Ritonavir?
MediHelp rates the interaction as contraindicated. Red yeast rice and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Red yeast rice contains monacolin K, identical to lovastatin, which is extensively metabolized by CYP3A4. Ritonavir is a potent CYP3A4 inhibitor and can greatly increase statin exposure, leading to myopathy and rhabdomyolysis.
How serious is the interaction between Red yeast rice and Ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop red yeast rice while on ritonavir. Choose an alternative lipid-lowering agent such as pravastatin or rosuvastatin with dose limits per labeling.
What other medicines interact with Red yeast rice?
MediHelp also lists interactions of Red yeast rice with, for example, Saquinavir, Tipranavir, Atazanavir. The full list is on the Red yeast rice page.
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