Interazioni tra farmaci
Red yeast rice + Tipranavir
Gravità: Controindicata
Red yeast rice and Tipranavir: contraindicated interaction.
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Sintesi
Red yeast rice contains monacolin K, identical to lovastatin, a CYP3A4 substrate. Tipranavir, given with ritonavir, strongly inhibits CYP3A4 and may substantially raise monacolin K levels, increasing the risk of muscle toxicity and rhabdomyolysis.
Cosa significa questa interazione in parole semplici
Red yeast rice and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Red yeast rice belongs to Gastrointestinal Tract; Tipranavir belongs to Anti Virals.
Perché avviene
Ritonavir-boosted tipranavir inhibits CYP3A4, increasing monacolin K (lovastatin) exposure.
Cosa fare
Avoid red yeast rice during tipranavir therapy. If a statin is needed, select one not reliant on CYP3A4 and monitor for muscle symptoms.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Red yeast rice
- Red yeast rice + Ritonavir Controindicata
- Red yeast rice + Saquinavir Controindicata
- Atazanavir + Red yeast rice Maggiore
- Atorvastatin + Red yeast rice Maggiore
- Conivaptan + Red yeast rice Maggiore
- Cyclosporine + Red yeast rice Maggiore
Altre interazioni di Tipranavir
- Alfuzosin + Tipranavir Controindicata
- Amiodarone + Tipranavir Controindicata
- Atorvastatin + Tipranavir Controindicata
- Avanafil + Tipranavir Controindicata
- Cisapride + Tipranavir Controindicata
- Colchicine + Tipranavir Controindicata
Domande frequenti
Can I take Red yeast rice with Tipranavir?
MediHelp rates the interaction as contraindicated. Red yeast rice and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Red yeast rice contains monacolin K, identical to lovastatin, a CYP3A4 substrate. Tipranavir, given with ritonavir, strongly inhibits CYP3A4 and may substantially raise monacolin K levels, increasing the risk of muscle toxicity and rhabdomyolysis.
How serious is the interaction between Red yeast rice and Tipranavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid red yeast rice during tipranavir therapy. If a statin is needed, select one not reliant on CYP3A4 and monitor for muscle symptoms.
What other medicines interact with Red yeast rice?
MediHelp also lists interactions of Red yeast rice with, for example, Ritonavir, Saquinavir, Atazanavir. The full list is on the Red yeast rice page.
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