医薬品リファレンス
Collagenase
Collagenase is a medicine in the class miscellaneous. It is used for burns.
- 薬効分類: Miscellaneous
- 効能・効果: burns
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Miscellaneous
- 既知の相互作用
- 1 (中等度: 1)
何に使われるか
作用のしくみ
Collagenase digests collagen in the physiological pH and temperature range, removing detritus and contributing to granulation tissue formation and epithelization. Collagen in healthy tissue or new granulation tissue is not attacked.
成人の通常用量（添付文書の要約）
Debridement of chronic dermal ulcers and severely burned areas: apply topically to the wound once daily, or more often if the dressing becomes soiled; stop when debridement is complete and granulation tissue is well established
妊娠と授乳
- 妊娠
- Unknown Injection (Xiaflex): blood levels are undetectable after injection; animal studies showed no harm; human case data are insufficient. Ointment (Santyl): not meaningfully absorbed. Use if needed; some labels advise postponing Xiaflex until after pregnancy.
- 授乳
- Safe No milk data. Blood levels are undetectable after Xiaflex injection and the ointment is not meaningfully absorbed, so infant exposure is unlikely. US label: weigh benefits. Do not apply ointment to the breast.
報告されている副作用
- Transient erythema of surrounding tissue
- Systemic hypersensitivity (one case reported)
禁忌
- Local or systemic hypersensitivity to collagenase
注意が必要な方
- Enzyme activity is best at pH 6 to 8; higher or lower pH reduces activity.
- Detergents and heavy metal ions (mercury, silver) in some antiseptics reduce activity. Cleanse the site with repeated normal saline washings first. Avoid soaks containing metal ions or acidic solutions.
- Monitor debilitated patients closely for systemic bacterial infection, as debriding enzymes may theoretically increase the risk of bacteremia.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (1)
- Collagenase + Silver sulfadiazine Moderate
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Collagenaseの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
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同じ分類のほかの薬剤
よくある質問
What is Collagenase used for?
Collagenase is a medicine in the class miscellaneous. It is used for Burns, Skin ulcers.
What side effects have been reported with Collagenase?
Transient erythema of surrounding tissue, Systemic hypersensitivity (one case reported).
Can Collagenase be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Injection (Xiaflex): blood levels are undetectable after injection; animal studies showed no harm; human case data are insufficient. Ointment (Santyl): not meaningfully absorbed. Use if needed; some labels advise postponing Xiaflex until after pregnancy. Breastfeeding: Safe. No milk data. Blood levels are undetectable after Xiaflex injection and the ointment is not meaningfully absorbed, so infant exposure is unlikely. US label: weigh benefits. Do not apply ointment to the breast.
What does Collagenase interact with?
MediHelp lists 1 known interactions for Collagenase. Moderate: 1. The most serious include Silver sulfadiazine.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
