医薬品リファレンス
Crizanlizumab
Crizanlizumab is a medicine in the class miscellaneous. It is used for sickle cell disease.
- 薬効分類: Miscellaneous
- 効能・効果: sickle cell disease
最終更新日 出典: US FDA label
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要点
- 薬効分類
- Miscellaneous
- 一般的な剤形
- 注射剤
- 一般的な規格
- 10 mg/ml
- 既知の相互作用
- 1 (中等度: 1)
- 商品名
- 2
- 国・市場
- 2
何に使われるか
作用のしくみ
Humanized IgG2 kappa monoclonal antibody that binds P-selectin and blocks its interactions with ligands including PSGL-1; it can also dissociate preformed P-selectin/PSGL-1 complex.
成人の通常用量（添付文書の要約）
Sickle cell disease (reduce frequency of vaso-occlusive crises): 5 mg/kg by intravenous infusion over 30 minutes at Week 0, Week 2, and every 4 weeks thereafter; may be given with or without hydroxyurea
妊娠と授乳
- 妊娠
- Unknown May cause fetal harm: in monkeys it increased fetal loss (abortions, stillbirths). Human data are insufficient. Sickle cell disease itself raises pregnancy risks. Use only if the benefit justifies the potential risk to the fetus.
- 授乳
- Unknown No data on milk levels or infant effects. Human IgG passes into milk; effects of the small infant exposure are unknown. Weigh the benefits of breastfeeding against the mother's need for treatment.
報告されている副作用
- Headache
- Arthralgia
- Nausea
- Back pain
- Fatigue
- Abdominal pain
注意が必要な方
- Infusion-related reactions (pain, nausea, vomiting, fatigue, dizziness, pruritus, diarrhea, pyrexia), some requiring hospitalization; mostly during first and second infusions. Interrupt or slow the infusion for mild/moderate reactions, discontinue for severe ones; consider premedication for later infusions.
- Infusion-related reactions can be indistinguishable from vaso-occlusive crisis events and may occur together.
- Use caution with corticosteroids in sickle cell disease unless clinically indicated; they may increase the risk of acute chest syndrome and fat embolism.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (1)
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Crizanlizumabの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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同じ分類のほかの薬剤
よくある質問
What is Crizanlizumab used for?
Crizanlizumab is a medicine in the class miscellaneous. It is used for Sickle cell disease.
What side effects have been reported with Crizanlizumab?
Headache, Arthralgia, Nausea, Back pain, Fatigue, Abdominal pain.
Can Crizanlizumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. May cause fetal harm: in monkeys it increased fetal loss (abortions, stillbirths). Human data are insufficient. Sickle cell disease itself raises pregnancy risks. Use only if the benefit justifies the potential risk to the fetus. Breastfeeding: Unknown. No data on milk levels or infant effects. Human IgG passes into milk; effects of the small infant exposure are unknown. Weigh the benefits of breastfeeding against the mother's need for treatment.
What does Crizanlizumab interact with?
MediHelp lists 1 known interactions for Crizanlizumab. Moderate: 1. The most serious include Exagamglogene autotemcel.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
