相互作用
Crizanlizumab + Exagamglogene autotemcel
重症度: 中等度
Crizanlizumab and Exagamglogene autotemcel: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Crizanlizumab given close to stem cell mobilization and myeloablative conditioning may compromise the collection of cells and the conditioning process. This could affect manufacture and engraftment of the gene-edited product.
この相互作用をわかりやすく説明すると
Crizanlizumab and Exagamglogene autotemcel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizanlizumab belongs to Miscellaneous; Exagamglogene autotemcel belongs to Miscellaneous.
なぜ起こるのか
The mechanism is not well established; crizanlizumab blocks P-selectin, which may affect stem cell mobilization and cell trafficking.
対処法
Stop crizanlizumab at least 8 weeks before mobilization and conditioning, as stated in labeling.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CrizanlizumabとExagamglogene autotemcelの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Exagamglogene autotemcelのその他の相互作用
よくある質問
Can I take Crizanlizumab with Exagamglogene autotemcel?
MediHelp rates the interaction as moderate. Crizanlizumab and Exagamglogene autotemcel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizanlizumab given close to stem cell mobilization and myeloablative conditioning may compromise the collection of cells and the conditioning process. This could affect manufacture and engraftment of the gene-edited product.
How serious is the interaction between Crizanlizumab and Exagamglogene autotemcel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop crizanlizumab at least 8 weeks before mobilization and conditioning, as stated in labeling.
What other medicines interact with Exagamglogene autotemcel?
MediHelp also lists interactions of Exagamglogene autotemcel with, for example, Deferasirox, Deferiprone, Deferoxamine. The full list is on the Exagamglogene autotemcel page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
