医薬品リファレンス
Elacestrant
Elacestrant is a medicine in the class oncology. It is used for breast cancer.
- 薬効分類: Oncology
- 効能・効果: breast cancer
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Oncology
- 一般的な剤形
- 錠剤
- 既知の相互作用
- 50 (重大: 20 · 中等度: 23 · 軽度: 7)
- 商品名
- 2
- 国・市場
- 2
何に使われるか
作用のしくみ
Elacestrant is an estrogen receptor antagonist that binds to ERα and inhibits estradiol-mediated proliferation of ER+ HER2- breast cancer cells, with degradation of ERα protein via the proteasomal pathway.
成人の通常用量（添付文書の要約）
ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer: 345 mg orally with food once daily until disease progression or unacceptable toxicity
妊娠と授乳
- 妊娠
- Unsafe Can cause fetal harm: in rats it caused embryo-fetal death and limb and skull malformations below human exposure; no human data. Verify pregnancy status first. Women, and men with female partners, should use effective contraception during treatment and for 1 week after.
- 授乳
- Unsafe No data on milk levels. Because of possible serious reactions in the infant, do not breastfeed during treatment and for 1 week after the last dose.
報告されている副作用
- Musculoskeletal pain
- Nausea
- Increased cholesterol
- Increased AST
- Increased triglycerides
- Fatigue
注意が必要な方
- Dyslipidemia: hypercholesterolemia and hypertriglyceridemia may occur; monitor lipid profile before starting and periodically.
- Embryo-fetal toxicity: can cause fetal harm; advise effective contraception during treatment and for 1 week after the last dose.
- May impair fertility in females and males of reproductive potential.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (50)
- Amobarbital + Elacestrant Major
- Apalutamide + Elacestrant Major
- Aprepitant + Elacestrant Major
- Armodafinil + Elacestrant Major
- Carbamazepine + Elacestrant Major
- Clarithromycin + Elacestrant Major
- Efavirenz + Elacestrant Major
- Elacestrant + Enzalutamide Major
- Elacestrant + Erythromycin Major
- Elacestrant + Eslicarbazepine Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Elacestrantの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Elacestrant used for?
Elacestrant is a medicine in the class oncology. It is used for Breast cancer.
What side effects have been reported with Elacestrant?
Musculoskeletal pain, Nausea, Increased cholesterol, Increased AST, Increased triglycerides, Fatigue.
Can Elacestrant be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: in rats it caused embryo-fetal death and limb and skull malformations below human exposure; no human data. Verify pregnancy status first. Women, and men with female partners, should use effective contraception during treatment and for 1 week after. Breastfeeding: Unsafe. No data on milk levels. Because of possible serious reactions in the infant, do not breastfeed during treatment and for 1 week after the last dose.
What does Elacestrant interact with?
MediHelp lists 50 known interactions for Elacestrant. Major: 20 · Moderate: 23 · Minor: 7. The most serious include Amobarbital, Apalutamide, Aprepitant.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
