相互作用
Aprepitant + Elacestrant
重症度: 重大
Aprepitant and Elacestrant: major interaction.
最終更新日
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概要
Aprepitant, a moderate CYP3A4 inhibitor, can raise elacestrant exposure. Higher levels may increase elacestrant adverse effects including nausea, dyslipidemia and musculoskeletal pain.
この相互作用をわかりやすく説明すると
Aprepitant and Elacestrant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Elacestrant belongs to Oncology.
なぜ起こるのか
Aprepitant inhibits CYP3A4, the main pathway of elacestrant metabolism.
対処法
Avoid concomitant use of elacestrant with moderate CYP3A4 inhibitors as labeled, and choose an antiemetic without CYP3A4 inhibition such as a 5-HT3 antagonist. If unavoidable, monitor for adverse effects.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AprepitantとElacestrantの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Aprepitantのその他の相互作用
Elacestrantのその他の相互作用
よくある質問
Can I take Aprepitant with Elacestrant?
MediHelp rates the interaction as major. Aprepitant and Elacestrant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aprepitant, a moderate CYP3A4 inhibitor, can raise elacestrant exposure. Higher levels may increase elacestrant adverse effects including nausea, dyslipidemia and musculoskeletal pain.
How serious is the interaction between Aprepitant and Elacestrant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use of elacestrant with moderate CYP3A4 inhibitors as labeled, and choose an antiemetic without CYP3A4 inhibition such as a 5-HT3 antagonist. If unavoidable, monitor for adverse effects.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
