医薬品リファレンス
Exemestane
Exemestane is a medicine in the class oncology. It is used for breast cancer.
- 薬効分類: Oncology
- 効能・効果: breast cancer
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Oncology
- 一般的な剤形
- 錠剤
- 一般的な規格
- 25 mg
- 既知の相互作用
- 66 (重大: 13 · 中等度: 32 · 軽度: 21)
- 商品名
- 10
- 国・市場
- 4
何に使われるか
作用のしくみ
Aromatase inhibitor - blocks conversion of androgens to estrogens by binding to the heme group of aromatase enzyme, which in turn inhibits its activity
成人の通常用量（添付文書の要約）
Advanced disease: 25 mg PO qDay; continue until tumor progression
妊娠と授乳
- 妊娠
- Unsafe Can cause fetal harm (animal studies); it is for postmenopausal women only. Contraindicated in pregnancy (EU label). Check pregnancy status before starting in women who could conceive and use effective contraception during treatment and for 1 month after the last dose.
- 授乳
- Unsafe No human milk data. Most sources say do not breastfeed during cancer treatment; the US label advises not to breastfeed during treatment and for 1 month after the last dose.
報告されている副作用
- Fatigue
- Nausea
- Insomnia
- Hot flashes
- Pain
- Depression
注意が必要な方
- Not indicated for breast cancer in premenopausal women
- Advise females of reproductive potential to use effective contraception during treatment and for 1 month after final dose
- Based on findings in animals, male and female fertility may be impaired by treatment
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (66)
- Bazedoxifene-conjugated estrogens + Exemestane Major
- Desogestrel-ethinyl estradiol + Exemestane Major
- Estradiol + Exemestane Major
- Estrogens conjugated synthetic + Exemestane Major
- Estrogens esterified + Exemestane Major
- Estropipate + Exemestane Major
- Ethinyl estradiol-drospirenone + Exemestane Major
- Ethinyl estradiol-levonorgestrel + Exemestane Major
- Ethinylestradiol + Exemestane Major
- Exemestane + Mitotane Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Exemestaneの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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よくある質問
What is Exemestane used for?
Exemestane is a medicine in the class oncology. It is used for Breast cancer.
What side effects have been reported with Exemestane?
Fatigue, Nausea, Insomnia, Hot flashes, Pain, Depression.
Can Exemestane be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm (animal studies); it is for postmenopausal women only. Contraindicated in pregnancy (EU label). Check pregnancy status before starting in women who could conceive and use effective contraception during treatment and for 1 month after the last dose. Breastfeeding: Unsafe. No human milk data. Most sources say do not breastfeed during cancer treatment; the US label advises not to breastfeed during treatment and for 1 month after the last dose.
What does Exemestane interact with?
MediHelp lists 66 known interactions for Exemestane. Major: 13 · Moderate: 32 · Minor: 21. The most serious include Bazedoxifene-conjugated estrogens, Desogestrel-ethinyl estradiol, Estradiol.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
