相互作用
Exemestane + Mitotane
重症度: 重大
Exemestane and Mitotane: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Mitotane is a strong CYP3A4 inducer that persists for weeks after discontinuation and can substantially lower exemestane concentrations. Reduced exposure may compromise the antiestrogenic effect of treatment.
この相互作用をわかりやすく説明すると
Exemestane and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Exemestane belongs to Oncology; Mitotane belongs to Oncology.
なぜ起こるのか
Mitotane induces CYP3A4, accelerating the metabolism of exemestane.
対処法
Increase exemestane to 50 mg daily after a meal when a strong CYP3A4 inducer is co-administered, and monitor treatment response. Consider that the induction continues after mitotane is stopped.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ExemestaneとMitotaneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Exemestaneのその他の相互作用
Mitotaneのその他の相互作用
よくある質問
Can I take Exemestane with Mitotane?
MediHelp rates the interaction as major. Exemestane and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitotane is a strong CYP3A4 inducer that persists for weeks after discontinuation and can substantially lower exemestane concentrations. Reduced exposure may compromise the antiestrogenic effect of treatment.
How serious is the interaction between Exemestane and Mitotane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase exemestane to 50 mg daily after a meal when a strong CYP3A4 inducer is co-administered, and monitor treatment response. Consider that the induction continues after mitotane is stopped.
What other medicines interact with Exemestane?
MediHelp also lists interactions of Exemestane with, for example, Bazedoxifene-conjugated estrogens, Desogestrel-ethinyl estradiol, Estradiol. The full list is on the Exemestane page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
