医薬品リファレンス
Fostemsavir
Fostemsavir is a medicine in the class anti virals. It is used for hiv.
- 薬効分類: Anti Virals
- 効能・効果: hiv
最終更新日 出典: US FDA label
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要点
- 薬効分類
- Anti Virals
- 一般的な剤形
- 錠剤
- 一般的な規格
- 600 mg
- 既知の相互作用
- 157 (併用禁忌: 6 · 重大: 5 · 中等度: 114 · 軽度: 32)
- 商品名
- 2
- 国・市場
- 2
何に使われるか
作用のしくみ
HIV-1 gp120-directed attachment inhibitor; HIV-1 antiretroviral agent. Fostemsavir is a prodrug of temsavir, the active moiety.
成人の通常用量（添付文書の要約）
HIV-1 infection in heavily treatment-experienced adults with multidrug-resistant HIV-1 (with other antiretrovirals): 600 mg tablet orally twice daily with or without food
妊娠と授乳
- 妊娠
- Unknown Insufficient human data to assess risk; no adverse developmental effects in rats and rabbits at clinically relevant exposures. Pregnancy registry exists. Used in heavily treated HIV when other options fail; continue if needed for viral control.
- 授乳
- Unknown Not known whether it is in human milk; it is in rat milk. Risks include HIV transmission, viral resistance and infant side effects. US guidance supports breastfeeding only with sustained viral suppression after counselling; otherwise avoid.
報告されている副作用
- Nausea
- Diarrhea
- Headache
- Abdominal pain
- Dyspepsia
- Fatigue
禁忌
- Previous hypersensitivity to fostemsavir or any component of the formulation.
- Coadministration with strong CYP3A inducers (e.g., enzalutamide, carbamazepine, phenytoin, rifampin, mitotane, St John's wort) because of loss of virologic response.
注意が必要な方
- Immune reconstitution syndrome, including inflammatory responses to opportunistic infections and autoimmune disorders, has been reported.
- QTc prolongation seen at higher than recommended doses; use caution with history of QT prolongation, cardiac disease, or drugs with Torsade de Pointes risk.
- Hepatic transaminase elevations in HBV/HCV co-infection, including hepatitis B reactivation; monitor liver chemistries.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (157)
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Efavirenz + Fostemsavir Major
- Fostemsavir + Lorlatinib Major
- Fostemsavir + Pimozide Major
- Fostemsavir + Sofosbuvir-velpatasvir-voxilaprevir Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Fostemsavirの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Fostemsavir used for?
Fostemsavir is a medicine in the class anti virals. It is used for HIV.
What side effects have been reported with Fostemsavir?
Nausea, Diarrhea, Headache, Abdominal pain, Dyspepsia, Fatigue.
Can Fostemsavir be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Insufficient human data to assess risk; no adverse developmental effects in rats and rabbits at clinically relevant exposures. Pregnancy registry exists. Used in heavily treated HIV when other options fail; continue if needed for viral control. Breastfeeding: Unknown. Not known whether it is in human milk; it is in rat milk. Risks include HIV transmission, viral resistance and infant side effects. US guidance supports breastfeeding only with sustained viral suppression after counselling; otherwise avoid.
What does Fostemsavir interact with?
MediHelp lists 157 known interactions for Fostemsavir. Contraindicated: 6 · Major: 5 · Moderate: 114 · Minor: 32. The most serious include Apalutamide, Carbamazepine, Enzalutamide.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
