相互作用
Fostemsavir + Sofosbuvir-velpatasvir-voxilaprevir
重症度: 重大
Fostemsavir and Sofosbuvir-velpatasvir-voxilaprevir: major interaction.
最終更新日
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概要
Fostemsavir's active metabolite temsavir inhibits OATP1B1/1B3 and BCRP, which raises voxilaprevir exposure. This may increase the risk of ALT elevations.
この相互作用をわかりやすく説明すると
Fostemsavir and Sofosbuvir-velpatasvir-voxilaprevir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fostemsavir belongs to Anti Virals; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
なぜ起こるのか
Temsavir inhibits OATP1B1/1B3 and BCRP, which reduces hepatic uptake and efflux of voxilaprevir.
対処法
Use an alternative HCV regimen if possible. If used together, monitor ALT and liver function.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FostemsavirとSofosbuvir-velpatasvir-voxilaprevirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Sofosbuvir-velpatasvir-voxilaprevirのその他の相互作用
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir 併用禁忌
Fostemsavirのその他の相互作用
よくある質問
Can I take Fostemsavir with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as major. Fostemsavir and Sofosbuvir-velpatasvir-voxilaprevir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fostemsavir's active metabolite temsavir inhibits OATP1B1/1B3 and BCRP, which raises voxilaprevir exposure. This may increase the risk of ALT elevations.
How serious is the interaction between Fostemsavir and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative HCV regimen if possible. If used together, monitor ALT and liver function.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
