医薬品リファレンス
Ivacaftor
Ivacaftor is a medicine in the class miscellaneous. It is used for cystic fibrosis.
- 薬効分類: Miscellaneous
- 効能・効果: cystic fibrosis
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Miscellaneous
- ATCコード
- R07AX02
- 一般的な剤形
- 錠剤
- 一般的な規格
- 150 mg
- 既知の相互作用
- 119 (併用禁忌: 1 · 重大: 10 · 中等度: 51 · 軽度: 57)
- 商品名
- 3
- 国・市場
- 3
何に使われるか
作用のしくみ
Ivacaftor is a CFTR potentiator that increases chloride transport by increasing the channel open probability (gating) of CFTR protein at the cell surface.
成人の通常用量（添付文書の要約）
Cystic fibrosis (adults and patients aged 6 years and older): 150 mg orally every 12 hours (300 mg total daily dose) with fat-containing food
妊娠と授乳
- 妊娠
- Unknown Limited human data (under 300 pregnancies); no harm in rats or rabbits at 5 to 11 times human exposure. EU label: as a precaution, preferable to avoid. Stopping may worsen cystic fibrosis, and CF teams often continue it, so decide with the CF specialist.
- 授乳
- Safe Low milk levels and very low infant blood levels; no infant harm reported, and expert groups consider it probably safe. EU label: weigh benefits. LactMed: check the infant's liver tests and eyes (cataracts) periodically, and test for CF, as it can mask it.
報告されている副作用
- Headache
- Upper respiratory tract infection
- Nasal congestion
- Nausea
- Rash
- Oropharyngeal pain
注意が必要な方
- Elevated transaminases: assess ALT/AST before starting, every 3 months in first year, then annually; interrupt dosing if ALT or AST greater than 5 times ULN.
- Hypersensitivity reactions including anaphylaxis reported postmarketing; discontinue and treat if serious signs develop.
- Intracranial hypertension reported with similar active ingredients; interrupt and refer if unusual headache or visual disturbances occur.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (119)
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
- Ivacaftor + Oxcarbazepine Major
- Ivacaftor + Phenobarbitone Major
- Ivacaftor + Phenytoin Major
- Ivacaftor + Rifabutin Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Ivacaftorの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
WebでPro+を14日間無料でお試し。カード登録不要。
よくある質問
What is Ivacaftor used for?
Ivacaftor is a medicine in the class miscellaneous. It is used for Cystic fibrosis.
What side effects have been reported with Ivacaftor?
Headache, Upper respiratory tract infection, Nasal congestion, Nausea, Rash, Oropharyngeal pain.
Can Ivacaftor be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data (under 300 pregnancies); no harm in rats or rabbits at 5 to 11 times human exposure. EU label: as a precaution, preferable to avoid. Stopping may worsen cystic fibrosis, and CF teams often continue it, so decide with the CF specialist. Breastfeeding: Safe. Low milk levels and very low infant blood levels; no infant harm reported, and expert groups consider it probably safe. EU label: weigh benefits. LactMed: check the infant's liver tests and eyes (cataracts) periodically, and test for CF, as it can mask it.
What does Ivacaftor interact with?
MediHelp lists 119 known interactions for Ivacaftor. Contraindicated: 1 · Major: 10 · Moderate: 51 · Minor: 57. The most serious include Ensitrelvir, Apalutamide, Carbamazepine.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
