相互作用
Clarithromycin + Ivacaftor
重症度: 重大
Clarithromycin and Ivacaftor: major interaction.
最終更新日 出典: US FDA label
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概要
Clarithromycin increases ivacaftor exposure and may increase ivacaftor-related adverse effects such as elevated transaminases, headache, and dizziness. The effect is that of a strong CYP3A inhibitor and requires a dose reduction of ivacaftor.
この相互作用をわかりやすく説明すると
Clarithromycin and Ivacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Ivacaftor belongs to Miscellaneous.
なぜ起こるのか
Clarithromycin is a strong CYP3A4 inhibitor that reduces the metabolism of ivacaftor, a sensitive CYP3A substrate.
対処法
Reduce ivacaftor to the labeled dose for use with strong CYP3A inhibitors (a reduced frequency, such as once or twice weekly depending on the formulation and age). Consider azithromycin as an alternative macrolide with minimal CYP3A inhibition.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClarithromycinとIvacaftorの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Ivacaftorのその他の相互作用
Clarithromycinのその他の相互作用
よくある質問
Can I take Clarithromycin with Ivacaftor?
MediHelp rates the interaction as major. Clarithromycin and Ivacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin increases ivacaftor exposure and may increase ivacaftor-related adverse effects such as elevated transaminases, headache, and dizziness. The effect is that of a strong CYP3A inhibitor and requires a dose reduction of ivacaftor.
How serious is the interaction between Clarithromycin and Ivacaftor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce ivacaftor to the labeled dose for use with strong CYP3A inhibitors (a reduced frequency, such as once or twice weekly depending on the formulation and age). Consider azithromycin as an alternative macrolide with minimal CYP3A inhibition.
What other medicines interact with Ivacaftor?
MediHelp also lists interactions of Ivacaftor with, for example, Ensitrelvir, Apalutamide, Carbamazepine. The full list is on the Ivacaftor page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
