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Leucovorin

Leucovorin is a medicine in the class miscellaneous. It is used for colorectal cancer.

最終更新日 出典: US FDA label

医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。

このページの臨床コンテンツは英語でのみ提供されています。

要点

薬効分類
Miscellaneous
一般的な剤形
注射剤
一般的な規格
15 mg
既知の相互作用
5 (重大: 3 · 中等度: 2)
商品名
3
国・市場
2

剤形、規格、商品名は国によって異なります。お手元の製品をご確認ください。

何に使われるか

作用のしくみ

Leucovorin is a mixture of diastereoisomers of 5-formyl tetrahydrofolic acid. It does not require reduction by dihydrofolate reductase to take part in folate one-carbon reactions, so it counteracts the therapeutic and toxic effects of folic acid antagonists such as methotrexate.

成人の通常用量（添付文書の要約）

Rescue after high-dose methotrexate (normal elimination): 15 mg IV or IM every 6 hours for 60 hours (10 doses total), starting 24 hours after the start of methotrexate infusion

添付文書の最初の用法・用量の行のみの要約です。用法・用量の全項目はアプリでご覧いただけます。

妊娠と授乳

妊娠
Safe Leucovorin (folinic acid) is a form of folate; no animal studies, and the US label says use only if clearly needed. Folate itself is not harmful in pregnancy. It is usually given with methotrexate or fluorouracil, which can harm the fetus: follow the partner drug's advice.
授乳
Safe Folinic acid and its forms are normal components of breast milk. Alone it is not expected to harm the infant (US label: use caution). When given with methotrexate or fluorouracil, the partner drug decides: breastfeeding is usually stopped during chemotherapy.

報告されている副作用

  • Stomatitis
  • Vomiting
  • Diarrhea
  • Nausea
  • Leukopenia
  • Alopecia

禁忌

  • Severe hypersensitivity reaction to leucovorin (folinic acid), levoleucovorin, or folic acid, including anaphylaxis

注意が必要な方

  • Hypersensitivity reactions including anaphylaxis and urticaria can occur; withhold or permanently discontinue based on severity
  • Hypercalcemia due to calcium content: do not exceed 160 mg per minute IV
  • Do not give intrathecally; may be harmful or fatal

妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。

主な相互作用 (5)

Pro+会員向け

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アカウントを作成してPro+トライアルを始めると、Leucovorinの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。

  • Dosing by age, kidney and liver function, and further dose lines
  • Renal and hepatic dose adjustments
  • Dosing in older adults
  • How to give it
  • Pharmacokinetics
  • Patient counselling points
  • IV preparation and dilution
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よくある質問

What is Leucovorin used for?

Leucovorin is a medicine in the class miscellaneous. It is used for Colorectal cancer, Folic acid deficiency, Overdose and poisoning.

What side effects have been reported with Leucovorin?

Stomatitis, Vomiting, Diarrhea, Nausea, Leukopenia, Alopecia.

Can Leucovorin be taken in pregnancy or while breastfeeding?

Pregnancy: Safe. Leucovorin (folinic acid) is a form of folate; no animal studies, and the US label says use only if clearly needed. Folate itself is not harmful in pregnancy. It is usually given with methotrexate or fluorouracil, which can harm the fetus: follow the partner drug's advice. Breastfeeding: Safe. Folinic acid and its forms are normal components of breast milk. Alone it is not expected to harm the infant (US label: use caution). When given with methotrexate or fluorouracil, the partner drug decides: breastfeeding is usually stopped during chemotherapy.

What does Leucovorin interact with?

MediHelp lists 5 known interactions for Leucovorin. Major: 3 · Moderate: 2. The most serious include Capecitabine, Fluorouracil, Glucarpidase.

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