相互作用
Leucovorin + Phenytoin
重症度: 中等度
Leucovorin and Phenytoin: moderate interaction.
最終更新日
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概要
Folinic acid may reduce phenytoin levels and anticonvulsant effect, raising the risk of breakthrough seizures. Folate also has been reported to lower phenytoin concentrations.
この相互作用をわかりやすく説明すると
Leucovorin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leucovorin belongs to Miscellaneous; Phenytoin belongs to Central Nervous System.
なぜ起こるのか
Folate may increase phenytoin metabolism; a pro-convulsant effect has also been proposed.
対処法
Monitor seizure control and phenytoin plasma concentrations during and after leucovorin treatment, adjusting the dose as needed.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LeucovorinとPhenytoinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Leucovorinのその他の相互作用
Phenytoinのその他の相互作用
よくある質問
Can I take Leucovorin with Phenytoin?
MediHelp rates the interaction as moderate. Leucovorin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Folinic acid may reduce phenytoin levels and anticonvulsant effect, raising the risk of breakthrough seizures. Folate also has been reported to lower phenytoin concentrations.
How serious is the interaction between Leucovorin and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and phenytoin plasma concentrations during and after leucovorin treatment, adjusting the dose as needed.
What other medicines interact with Leucovorin?
MediHelp also lists interactions of Leucovorin with, for example, Capecitabine, Fluorouracil, Glucarpidase. The full list is on the Leucovorin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
