医薬品リファレンス
Linaclotide
Linaclotide is a medicine in the class gastrointestinal tract. It is used for constipation.
- 薬効分類: Gastrointestinal Tract
- 効能・効果: constipation
最終更新日 出典: US FDA label, EMA SmPC
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Gastrointestinal Tract
- ATCコード
- A06AX04
- 一般的な剤形
- カプセル剤
- 既知の相互作用
- 2 (中等度: 2)
- 商品名
- 3
- 国・市場
- 2
何に使われるか
作用のしくみ
Linaclotide and its active metabolite are guanylate cyclase-C agonists acting locally on the intestinal epithelium. Raised cGMP stimulates chloride and bicarbonate secretion via CFTR, increasing intestinal fluid and accelerating transit.
成人の通常用量（添付文書の要約）
IBS-C: 290 mcg orally once daily
妊娠と授乳
- 妊娠
- Unknown Negligibly absorbed systemically; maternal use not expected to result in fetal exposure. Available human data insufficient to inform drug-associated risk.
- 授乳
- Safe Linaclotide and its active metabolite were not detected in milk; exposure of breastfed infants not expected. Consider benefits of breastfeeding with maternal need.
報告されている副作用
- Diarrhea
- Abdominal pain
- Flatulence
- Abdominal distension
- Viral gastroenteritis
- Headache
警告（枠囲み警告）
- Risk of serious dehydration in pediatric patients less than 2 years of age. Contraindicated in this age group; in neonatal mice a single clinically relevant adult oral dose caused deaths due to dehydration.
禁忌
- Patients less than 2 years of age due to risk of serious dehydration.
- Known or suspected mechanical gastrointestinal obstruction.
注意が必要な方
- Severe diarrhea may occur; post-marketing cases with dizziness, syncope, hypotension and electrolyte abnormalities (hypokalemia, hyponatremia) required hospitalization or IV fluids.
- Insufficient data on GC-C intestinal expression in children under 2 years to assess risk of diarrhea and its serious consequences.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (2)
- Linaclotide + Lubiprostone Moderate
- Linaclotide + Mosapride Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Linaclotideの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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関連するクイックリード
よくある質問
What is Linaclotide used for?
Linaclotide is a medicine in the class gastrointestinal tract. It is used for Constipation, Irritable bowel syndrome.
What side effects have been reported with Linaclotide?
Diarrhea, Abdominal pain, Flatulence, Abdominal distension, Viral gastroenteritis, Headache. Serious warning: Risk of serious dehydration in pediatric patients less than 2 years of age.
Can Linaclotide be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Negligibly absorbed systemically; maternal use not expected to result in fetal exposure. Available human data insufficient to inform drug-associated risk. Breastfeeding: Safe. Linaclotide and its active metabolite were not detected in milk; exposure of breastfed infants not expected. Consider benefits of breastfeeding with maternal need.
What does Linaclotide interact with?
MediHelp lists 2 known interactions for Linaclotide. Moderate: 2. The most serious include Lubiprostone, Mosapride.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
