相互作用
Linaclotide + Mosapride
重症度: 中等度
Linaclotide and Mosapride: moderate interaction.
最終更新日 出典: US FDA label
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概要
Mosapride is a prokinetic and linaclotide a secretagogue, and together they may increase the risk of diarrhea, cramping and dehydration. No formal interaction studies are known, so the concern is predicted from pharmacology. Diarrhea is already the most common adverse effect of linaclotide.
この相互作用をわかりやすく説明すると
Linaclotide and Mosapride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linaclotide belongs to Gastrointestinal Tract; Mosapride belongs to Gastrointestinal Tract.
なぜ起こるのか
Pharmacodynamic: mosapride is a 5-HT4 agonist that increases gut motility, while linaclotide activates guanylate cyclase-C and increases intestinal fluid secretion and transit.
対処法
Avoid routine combination. If used together, start at low doses and counsel patients about hydration.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LinaclotideとMosaprideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Mosaprideのその他の相互作用
Linaclotideのその他の相互作用
よくある質問
Can I take Linaclotide with Mosapride?
MediHelp rates the interaction as moderate. Linaclotide and Mosapride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mosapride is a prokinetic and linaclotide a secretagogue, and together they may increase the risk of diarrhea, cramping and dehydration. No formal interaction studies are known, so the concern is predicted from pharmacology. Diarrhea is already the most common adverse effect of linaclotide.
How serious is the interaction between Linaclotide and Mosapride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination. If used together, start at low doses and counsel patients about hydration.
What other medicines interact with Mosapride?
MediHelp also lists interactions of Mosapride with, for example, Lubiprostone, Prucalopride. The full list is on the Mosapride page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
