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Lomitapide

Lomitapide is a medicine in the class cardiovascular. It is used for hypercholesterolemia.

最終更新日 出典: US FDA label, EMA SmPC

医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。

このページの臨床コンテンツは英語でのみ提供されています。

要点

薬効分類
Cardiovascular
ATCコード
C10AX12
一般的な剤形
カプセル剤
既知の相互作用
146 (併用禁忌: 16 · 重大: 28 · 中等度: 68 · 軽度: 34)
商品名
2
国・市場
2

剤形、規格、商品名は国によって異なります。お手元の製品をご確認ください。

何に使われるか

作用のしくみ

Binds and inhibits microsomal triglyceride transfer protein (MTP), preventing assembly of apo B-containing lipoproteins in enterocytes and hepatocytes. This inhibits chylomicron and VLDL synthesis and reduces plasma LDL-C.

成人の通常用量（添付文書の要約）

HoFH (18 years and older): start 5 mg orally once daily; titrate per Table 1 (weeks 0 to 2 at 5 mg, then 10 mg, 20 mg, 40 mg); maximum 60 mg daily from week 15, based on LDL-C target, safety and tolerability

添付文書の最初の用法・用量の行のみの要約です。用法・用量の全項目はアプリでご覧いただけます。

通常の服用方法

Statins are taken by mouth once a day, long term, with blood tests to check the response and liver function.

正確な用量、服用時間、期間は処方者と製品の添付文書に従ってください。MediHelpではログイン後に用法・用量の全項目を表示します。

妊娠と授乳

妊娠
Unsafe Contraindicated in pregnancy; may cause fetal harm based on animal studies. Discontinue if pregnancy is detected.
授乳
Unsafe No data on presence in milk; breastfeeding is not recommended because of potential serious adverse reactions including hepatotoxicity.

報告されている副作用

  • Diarrhea
  • Nausea
  • Dyspepsia
  • Abdominal pain
  • Vomiting
  • Chest pain

警告（枠囲み警告）

  • Risk of hepatotoxicity: can raise transaminases and increase hepatic fat (steatosis), a possible risk factor for steatohepatitis and cirrhosis. Measure ALT, AST, alkaline phosphatase and bilirubin before starting, then ALT and AST regularly. Adjust dose if ALT or AST ≥3 times ULN and discontinue for clinically significant liver toxicity. Available only through the JUXTAPID REMS Program. Prescribe only for HoFH.

禁忌

  • Pregnancy
  • Concomitant use with moderate or strong CYP3A4 inhibitors
  • Moderate or severe hepatic impairment (Child-Pugh B or C) and active liver disease, including unexplained persistent transaminase elevations

注意が必要な方

  • Hepatotoxicity: transaminase elevations and hepatic steatosis; monitor liver tests before each dose increase or monthly in the first year, then at least every 3 months
  • Embryo-fetal toxicity: may cause fetal harm; negative pregnancy test before starting and effective contraception during treatment and for two weeks after
  • Reduced absorption of fat-soluble vitamins and fatty acids; daily vitamin E and essential fatty acid supplements needed

Unexplained muscle pain, tenderness or weakness while taking a statin should be reported promptly. Statins are not used in pregnancy, and some other medicines raise their levels and risk.

妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。

主な相互作用 (146)

All 146 interactions, with severity and what to do

Pro+会員向け

ページ全体を見る

アカウントを作成してPro+トライアルを始めると、Lomitapideの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。

  • Dosing by age, kidney and liver function, and further dose lines
  • Renal and hepatic dose adjustments
  • Paediatric dosing
  • Dosing in older adults
  • How to give it
  • Pharmacokinetics
  • Patient counselling points
  • Food interactions
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同じ分類のほかの薬剤

よくある質問

What is Lomitapide used for?

Lomitapide is a medicine in the class cardiovascular. It is used for Hypercholesterolemia.

What side effects have been reported with Lomitapide?

Diarrhea, Nausea, Dyspepsia, Abdominal pain, Vomiting, Chest pain. Serious warning: Risk of hepatotoxicity: can raise transaminases and increase hepatic fat (steatosis), a possible risk factor for steatohepatitis and cirrhosis.

Can Lomitapide be taken in pregnancy or while breastfeeding?

Pregnancy: Unsafe. Contraindicated in pregnancy; may cause fetal harm based on animal studies. Discontinue if pregnancy is detected. Breastfeeding: Unsafe. No data on presence in milk; breastfeeding is not recommended because of potential serious adverse reactions including hepatotoxicity.

What does Lomitapide interact with?

MediHelp lists 146 known interactions for Lomitapide. Contraindicated: 16 · Major: 28 · Moderate: 68 · Minor: 34. The most serious include Aprepitant, Clarithromycin, Crizotinib.

完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで

MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。

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