相互作用
Crizotinib + Lomitapide
重症度: 併用禁忌
Crizotinib and Lomitapide: contraindicated interaction.
最終更新日
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概要
Crizotinib is a moderate CYP3A4 inhibitor and lomitapide is a sensitive CYP3A4 substrate, so exposure to lomitapide can rise markedly. This increases the risk of hepatotoxicity and gastrointestinal adverse effects.
この相互作用をわかりやすく説明すると
Crizotinib and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Crizotinib belongs to Oncology; Lomitapide belongs to Cardiovascular.
なぜ起こるのか
Crizotinib inhibits CYP3A4, reducing first-pass and systemic metabolism of lomitapide.
対処法
Avoid the combination; labeling for lomitapide advises against moderate and strong CYP3A4 inhibitors. Use an alternative lipid-lowering strategy during crizotinib treatment.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、CrizotinibとLomitapideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Crizotinibのその他の相互作用
Lomitapideのその他の相互作用
よくある質問
Can I take Crizotinib with Lomitapide?
MediHelp rates the interaction as contraindicated. Crizotinib and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Crizotinib is a moderate CYP3A4 inhibitor and lomitapide is a sensitive CYP3A4 substrate, so exposure to lomitapide can rise markedly. This increases the risk of hepatotoxicity and gastrointestinal adverse effects.
How serious is the interaction between Crizotinib and Lomitapide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; labeling for lomitapide advises against moderate and strong CYP3A4 inhibitors. Use an alternative lipid-lowering strategy during crizotinib treatment.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lonafarnib, Pimozide. The full list is on the Crizotinib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
