医薬品リファレンス
Lubiprostone
Lubiprostone is a medicine in the class gastrointestinal tract. It is used for constipation.
- 薬効分類: Gastrointestinal Tract
- 効能・効果: constipation
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Gastrointestinal Tract
- 一般的な剤形
- カプセル剤
- 一般的な規格
- 24 mcg, 8 mcg
- 既知の相互作用
- 3 (中等度: 2 · 軽度: 1)
- 商品名
- 12
- 国・市場
- 2
何に使われるか
作用のしくみ
Locally acting chloride channel activator; increases intestinal fluid secretion and intestinal motility; acts locally at apical portion of intestine.
成人の通常用量（添付文書の要約）
Irritable Bowel Syndrome With Constipation: 8 mcg PO BID
妊娠と授乳
- 妊娠
- Unknown Limited human data. Little drug reaches the blood (one metabolite is measurable). No birth defects in rats or rabbits; fetal loss in guinea pigs was probably due to maternal toxicity. Use only if the benefit justifies the risk; osmotic laxatives or fibre are usual first choices.
- 授乳
- Safe No human milk data; neither lubiprostone nor its active metabolite was found in rat milk, so little is expected in human milk. LactMed: not expected to harm the infant. If used, watch the infant for diarrhoea.
報告されている副作用
- Headache
- Diarrhea
- Nausea
禁忌
- Hypersensitivity
- Mechanical GI obstruction
注意が必要な方
- Syncope and hypotension reported, some of which required hospitalization; most cases occurred in patients taking 24 mcg twice daily and some occurred within hours.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (3)
- Linaclotide + Lubiprostone Moderate
- Lubiprostone + Mosapride Moderate
- Deflazacort + Lubiprostone Minor
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Lubiprostoneの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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よくある質問
What is Lubiprostone used for?
Lubiprostone is a medicine in the class gastrointestinal tract. It is used for Constipation, Irritable bowel syndrome.
What side effects have been reported with Lubiprostone?
Headache, Diarrhea, Nausea.
Can Lubiprostone be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data. Little drug reaches the blood (one metabolite is measurable). No birth defects in rats or rabbits; fetal loss in guinea pigs was probably due to maternal toxicity. Use only if the benefit justifies the risk; osmotic laxatives or fibre are usual first choices. Breastfeeding: Safe. No human milk data; neither lubiprostone nor its active metabolite was found in rat milk, so little is expected in human milk. LactMed: not expected to harm the infant. If used, watch the infant for diarrhoea.
What does Lubiprostone interact with?
MediHelp lists 3 known interactions for Lubiprostone. Moderate: 2 · Minor: 1. The most serious include Linaclotide, Mosapride, Deflazacort.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
