医薬品リファレンス
Mafenide
Mafenide is a medicine in the class dermatology. It is used for burns.
- 薬効分類: Dermatology
- 効能・効果: burns
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Dermatology
- 一般的な剤形
- クリーム剤
- 一般的な規格
- 85 mg/g
- 既知の相互作用
- 1 (重大: 1)
- 商品名
- 1
- 国・市場
- 1
何に使われるか
作用のしくみ
Applied topically, it markedly reduces the bacterial population in the avascular tissues of second- and third-degree burns and exerts bacteriostatic action against many gram-negative and gram-positive organisms, including Pseudomonas aeruginosa.
成人の通常用量（添付文書の要約）
Second- and third-degree burns (adjunctive): apply cream topically with sterile gloved hand once or twice daily to a thickness of approximately 1/16 inch; keep burned areas covered with cream at all times; continue until healing is progressing well or site is ready for grafting.
妊娠と授乳
- 妊娠
- Unknown Burn cream/solution; absorbed through large burns. No animal reproduction studies; fetal risk unknown. US label: not recommended in women who could become pregnant unless the burn covers more than 20% of the body or the benefit outweighs the possible fetal risk.
- 授乳
- Unknown Not known if it passes into milk; no LactMed or e-lactancia record. US label: decide whether to stop breastfeeding or the drug. Large burns give real absorption (it can cause metabolic acidosis), so avoid if possible; never apply to the breast.
報告されている副作用
- Pain or burning sensation on application
- Rash
- Itching
- Facial edema
- Eosinophilia
- Tachypnea or hyperventilation
禁忌
- Hypersensitivity to the drug; cross-sensitivity to other sulfonamides is not known.
注意が必要な方
- Fatal hemolytic anemia with disseminated intravascular coagulation, presumably related to G6PD deficiency, has been reported.
- Contains sodium metabisulfite, which may cause allergic-type reactions including anaphylaxis and asthmatic episodes in susceptible people.
- Mafenide and its metabolite inhibit carbonic anhydrase, which may cause metabolic acidosis; monitor acid-base balance closely, especially in extensive second-degree burns and pulmonary or renal dysfunction.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (1)
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アカウントを作成してPro+トライアルを始めると、Mafenideの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
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同じ分類のほかの薬剤
よくある質問
What is Mafenide used for?
Mafenide is a medicine in the class dermatology. It is used for Burns.
What side effects have been reported with Mafenide?
Pain or burning sensation on application, Rash, Itching, Facial edema, Eosinophilia, Tachypnea or hyperventilation.
Can Mafenide be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Burn cream/solution; absorbed through large burns. No animal reproduction studies; fetal risk unknown. US label: not recommended in women who could become pregnant unless the burn covers more than 20% of the body or the benefit outweighs the possible fetal risk. Breastfeeding: Unknown. Not known if it passes into milk; no LactMed or e-lactancia record. US label: decide whether to stop breastfeeding or the drug. Large burns give real absorption (it can cause metabolic acidosis), so avoid if possible; never apply to the breast.
What does Mafenide interact with?
MediHelp lists 1 known interactions for Mafenide. Major: 1. The most serious include Dichlorphenamide.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
