医薬品リファレンス
Pegfilgrastim
Pegfilgrastim is a medicine in the class miscellaneous. It is used for neutropenia.
- 薬効分類: Miscellaneous
- 効能・効果: neutropenia
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Miscellaneous
- ATCコード
- L03AA13
- 一般的な剤形
- 注射剤
- 一般的な規格
- 6 mg/.6 ml, 6 mg, 6 mg/0.6 ml
- 既知の相互作用
- 1 (中等度: 1)
- 商品名
- 24
- 国・市場
- 3
何に使われるか
作用のしくみ
Recombinant PEG-conjugated human G-CSF; acts on hematopoietic cells by binding to specific cell surface receptors, thereby stimulating proliferation, differentiation, commitment, and end-cell functional activation
成人の通常用量（添付文書の要約）
Prevention of Chemotherapy-induced Neutropenia: 6 mg SC once per chemotherapy cycle
妊娠と授乳
- 妊娠
- Unknown Limited pegfilgrastim data; filgrastim studies show no link to birth defects or miscarriage. No harm in rats at 10 times the dose; rabbit fetal loss only with maternal toxicity. EU label: not recommended in pregnancy or without contraception. Filgrastim has more data; use only if clearly needed.
- 授乳
- Safe No milk data for pegfilgrastim. EU label: risk cannot be excluded; decide whether to stop breastfeeding or the drug. LactMed (filgrastim record, covers pegfilgrastim): G-CSFs pass poorly into milk and are not absorbed by the infant's gut, so harm is unlikely; some advise pausing feeds for 3 days.
報告されている副作用
- Bone pain
- Pain in extremity
- Leukocytosis
- Sickle cell crisis
注意が必要な方
- Severe and sometimes fatal sickle cell crises can occur in patients with sickle cell disorders; discontinue therapy if sickle cell crisis occurs
- ARDS reported; evaluate symptoms, including fever, pulmonary infiltrates, or respiratory distress; discontinue if ARDS occurs
- Rare cases of splenic rupture may occur; evaluate if patient experiences left upper abdominal and/or shoulder tip pain
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (1)
- Ifosfamide + Pegfilgrastim Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Pegfilgrastimの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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よくある質問
What is Pegfilgrastim used for?
Pegfilgrastim is a medicine in the class miscellaneous. It is used for Neutropenia, Radiation syndrome.
What side effects have been reported with Pegfilgrastim?
Bone pain, Pain in extremity, Leukocytosis, Sickle cell crisis.
Can Pegfilgrastim be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited pegfilgrastim data; filgrastim studies show no link to birth defects or miscarriage. No harm in rats at 10 times the dose; rabbit fetal loss only with maternal toxicity. EU label: not recommended in pregnancy or without contraception. Filgrastim has more data; use only if clearly needed. Breastfeeding: Safe. No milk data for pegfilgrastim. EU label: risk cannot be excluded; decide whether to stop breastfeeding or the drug. LactMed (filgrastim record, covers pegfilgrastim): G-CSFs pass poorly into milk and are not absorbed by the infant's gut, so harm is unlikely; some advise pausing feeds for 3 days.
What does Pegfilgrastim interact with?
MediHelp lists 1 known interactions for Pegfilgrastim. Moderate: 1. The most serious include Ifosfamide.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
