相互作用
Ifosfamide + Pegfilgrastim
重症度: 中等度
Ifosfamide and Pegfilgrastim: moderate interaction.
最終更新日
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概要
Pegfilgrastim sensitizes rapidly dividing myeloid precursors to cytotoxic drugs, so giving it around the time of ifosfamide may increase marrow toxicity and reduce its benefit. Its long-acting nature makes timing important.
この相互作用をわかりやすく説明すると
Ifosfamide and Pegfilgrastim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Pegfilgrastim belongs to Miscellaneous.
なぜ起こるのか
Growth factor-induced proliferation of myeloid progenitors increases their susceptibility to cytotoxic chemotherapy.
対処法
Give pegfilgrastim no sooner than 24 hours after completing ifosfamide, and not within 14 days before the next chemotherapy cycle. Monitor blood counts.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、IfosfamideとPegfilgrastimの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ifosfamideのその他の相互作用
よくある質問
Can I take Ifosfamide with Pegfilgrastim?
MediHelp rates the interaction as moderate. Ifosfamide and Pegfilgrastim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegfilgrastim sensitizes rapidly dividing myeloid precursors to cytotoxic drugs, so giving it around the time of ifosfamide may increase marrow toxicity and reduce its benefit. Its long-acting nature makes timing important.
How serious is the interaction between Ifosfamide and Pegfilgrastim?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give pegfilgrastim no sooner than 24 hours after completing ifosfamide, and not within 14 days before the next chemotherapy cycle. Monitor blood counts.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
